U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CESA4 cellulose synthase A4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834426, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CESA4
Official Full Name
cellulose synthase A4
Primary source
TAIR:AT5G44030
Locus tag
AT5G44030
See related
Araport:AT5G44030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cellulose synthase A4; IRREGULAR XYLEM 5; IRX5; MRH10.14; MRH10_14; NWS2
Summary
Encodes a cellulose synthase involved in secondary cell wall biosynthesis. Confers resistance towards bacterial and fungal pathogens, independent of salicylic acid, ethylene and jasmonate signaling.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CESA4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (17714390..17719723)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fanconi anemia group F protein (FANCF) Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene eisosome SEG2-like protein Neighboring gene MATE efflux family protein Neighboring gene embryo sac development arrest protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Impairment of cellulose synthases required for Arabidopsis secondary cell wall formation enhances disease resistance. Hernández-Blanco C, et al. Plant Cell, 2007 Mar. PMID 17351116, Free PMC Article
  2. Exploiting CELLULOSE SYNTHASE (CESA) Class Specificity to Probe Cellulose Microfibril Biosynthesis. Kumar M, et al. Plant Physiol, 2018 May. PMID 29523715, Free PMC Article
  3. Phylogenetically distinct cellulose synthase genes support secondary wall thickening in arabidopsis shoot trichomes and cotton fiber. Betancur L, et al. J Integr Plant Biol, 2010 Feb. PMID 20377682
  4. Interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall. Timmers J, et al. FEBS Lett, 2009 Mar 18. PMID 19258017
  5. Elucidating the mechanisms of assembly and subunit interaction of the cellulose synthase complex of Arabidopsis secondary cell walls. Atanassov II, et al. J Biol Chem, 2009 Feb 6. PMID 19056734

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CESA4 role in the cellulose microfibril biosynthesis in the secondary cell wall.
    Title: Exploiting CELLULOSE SYNTHASE (CESA) Class Specificity to Probe Cellulose Microfibril Biosynthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_001344528.1
NM_001344529.1
NM_123770.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cellulose synthase (UDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables cellulose synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in cell wall thickening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellulose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellulose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellulose biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in ethylene-activated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in jasmonic acid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within plant-type cell wall biogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in salicylic acid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cellulose synthase A4
NP_199216.2
  • cellulose synthase A4 (CESA4); FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: cellulose biosynthetic process, plant-type cell wall biogenesis, defense response to bacterium, defense response to fungus, secondary cell wall biogenesis; LOCATED IN: membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150); BEST Arabidopsis thaliana protein match is: Cellulose synthase family protein (TAIR:AT5G05170.1); Has 3263 Blast hits to 2832 proteins in 640 species: Archae - 9; Bacteria - 1071; Metazoa - 1; Fungi - 31; Plants - 2051; Viruses - 7; Other Eukaryotes - 93 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    17714390..17719723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123770.4 → NP_199216.2  cellulose synthase A4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199216.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WQW9, Q84JA6, Q8GZN8, Q9FNC3
    UniProtKB/TrEMBL
    A0A068FIL6, A0A178ULT0, A0A5S9YD41
    Conserved Domains (3) summary
    PLN02915
    Location:6 → 1049
    PLN02915; cellulose synthase A [UDP-forming], catalytic subunit
    pfam14569
    Location:16 → 81
    zf-UDP; Zinc-binding RING-finger
    cl11394
    Location:463 → 798
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. NM_001344528.1 → NP_001332727.1  cellulose synthase A4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178ULT0, A0A1R7T3H6, A0A5S9YD41

  3. NM_001344529.1 → NP_001332726.1  cellulose synthase A4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1R7T3H5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84JA6.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.