COP8 Proteasome component (PCI) domain protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: COP8
Official Full Name: Proteasome component (PCI) domain protein
Primary source: TAIR:AT5G42970
Locus tag: AT5G42970
See related: Araport:AT5G42970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATS4; CONSTITUTIVE PHOTOMORPHOGENIC 14; CONSTITUTIVE PHOTOMORPHOGENIC 8; COP14; COP9 SIGNALOSOME SUBUNIT 4; CSN4; EMB134; EMBRYO DEFECTIVE 134; FUS4; FUS8; FUSCA 4; FUSCA 8; MBD2.17; MBD2_17
Summary: encodes subunit 4 of COP9 signalosome complex. sequence is similar to a subunit of the 19S regulatory particle of the 26S proteasome. recessive mutation causes derepression of photomorphogenesis.
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Genomic context

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See COP8 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 13

Sequence:: Chromosome: 5; NC_003076.8 (17237153..17240816, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP
Title: TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
Title: The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_123663.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photomorphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein deneddylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of COP9 signalosome	IPI Inferred from Physical Interaction more info	PubMed
part_of COP9 signalosome	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Proteasome component (PCI) domain protein

NP_199111.1

CONSTITUTIVE PHOTOMORPHOGENIC 8 (COP8); FUNCTIONS IN: protein binding; INVOLVED IN: cullin deneddylation, negative regulation of photomorphogenesis, G2 phase of mitotic cell cycle, photomorphogenesis; LOCATED IN: signalosome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Proteasome component (PCI) domain (InterPro:IPR000717); BEST Arabidopsis thaliana protein match is: regulatory particle non-ATPase subunit 5B (TAIR:AT5G64760.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

17237153..17240816 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123663.3 → NP_199111.1 Proteasome component (PCI) domain protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199111.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L5U0, Q9FMM1, Q9SW74

UniProtKB/TrEMBL

A0A178UIE2, A0A384KTP3, A0A7G2FE21, Q1H5B6

Conserved Domains (2) summary

COG5071
Location:92 → 384

RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

pfam01399
Location:263 → 362

PCI; PCI domain