RING/U-box superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: RING/U-box superfamily protein
Primary source: TAIR:AT5G41580
Locus tag: AT5G41580
See related: Araport:AT5G41580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MBK23.10; MBK23_10; PIAL2; PROTEIN INHIBITOR OF ACTIVATED STAT LIKE 2
Summary: Encodes an SP-RING domain containing protein that functions in sumolaytion and is involved in positive regulation of sulfur metabolism and stress response.
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 16

Sequence:: Chromosome: 5; NC_003076.8 (16626185..16630820, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the conserved PIAL2 interaction domain is exclusively responsible for the interaction of PIAL2 with MOM1
Title: Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.
study suggests that PIAL1 and PIAl2 act as components of the MOM1-containing complex to mediate transcriptional silencing at heterochromatin regions.
Title: The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.
PIAL1 and PIAL2 function as small ubiquitin-related modifier (SUMO) ligases capable of SUMO chain formation and require the SUMO-modified SUMO-conjugating enzyme SCE1 for optimal activity.
Title: Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_123522.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables SUMO transferase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of sulfur metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene silencing by regulatory ncRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RING/U-box superfamily protein

NP_198973.3

RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, MIZ-type (InterPro:IPR004181); BEST Arabidopsis thaliana protein match is: zinc ion binding;zinc ion binding (TAIR:AT1G08910.1); Has 2409 Blast hits to 1813 proteins in 283 species: Archae - 4; Bacteria - 96; Metazoa - 1110; Fungi - 536; Plants - 146; Viruses - 31; Other Eukaryotes - 486 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16626185..16630820 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123522.4 → NP_198973.3 RING/U-box superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198973.3

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JYG0, Q0WP46, Q9FFS2

UniProtKB/TrEMBL

A0A178UER0, A0A178UGV0, A0A5S9YCC4

Conserved Domains (2) summary

pfam05109
Location:531 → 758

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd16650
Location:310 → 357

SP-RING_PIAS_like; SP-RING finger found in the Siz/PIAS RING (SP-RING) family of SUMO E3 ligases