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XPB2 homolog of Xeroderma pigmentosum complementation group B 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834138, updated on 18-Sep-2024

Summary

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Official Symbol
XPB2
Official Full Name
homolog of Xeroderma pigmentosum complementation group B 2
Primary source
TAIR:AT5G41360
Locus tag
AT5G41360
See related
Araport:AT5G41360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS HOMOLOG OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP B 2; ATXPB2; homolog of Xeroderma pigmentosum complementation group B 2; MYC6.7; MYC6_7
Summary
Encodes XPB2, a DNA repair protein and transcription factor. Arabidopsis thaliana has duplicated XPB gene (AtXPB1 and AtXPB2, with high similarity to each other). XPB proteins are involved in both DNA repair and transcription, they are component of the transcription factor IIH (TFIIH) and are responsible for DNA helicase activity during nucleotide (nt) excision repair (NER). Complementation assays in yeast rad25 mutant strains suggest the involvement of AtXPB2 in DNA repair. Although both genes are expressed in a constitutive manner during the plant life cycle, Northern blot analyses suggest that light modulates the expression level of both XPB copies.
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Genomic context

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See XPB2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Sequence:
Chromosome: 5; NC_003076.8 (16544333..16549327)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme 4 Neighboring gene RING/U-box superfamily protein Neighboring gene DNA repair helicase XPB1-like protein Neighboring gene CCT motif family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional XPB/RAD25 redundancy in Arabidopsis genome: characterization of AtXPB2 and expression analysis. Morgante PG, et al. Gene, 2005 Jan 3. PMID 15656976
  2. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
  3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_123501.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to UV-B IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
homolog of Xeroderma pigmentosum complementation group B 2
NP_568591.1
  • homolog of Xeroderma pigmentosum complementation group B 2 (XPB2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to UV-B, N-terminal protein myristoylation; EXPRESSED IN: whole plant; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Restriction endonuclease, type I, R subunit/Type III, Res subunit (InterPro:IPR006935), DEAD-like helicase, N-terminal (InterPro:IPR014001), Xeroderma pigmentosum group B protein (XP-B) (InterPro:IPR001161), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: homolog of xeroderma pigmentosum complementation group B 1 (TAIR:AT5G41370.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    16544333..16549327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344402.1 → NP_001331083.1  homolog of Xeroderma pigmentosum complementation group B 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BCS7, A0A5S9Y9Z5

  2. NM_123501.3 → NP_568591.1  homolog of Xeroderma pigmentosum complementation group B 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568591.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FN64, Q9FUG4
    UniProtKB/TrEMBL
    A0A178UFA0, A0A178UFV9
    Conserved Domains (1) summary
    TIGR00603
    Location:51 → 763
    rad25; DNA repair helicase rad25
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FUG4.1

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