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ATR Ataxia telangiectasia-mutated and RAD3-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834082, updated on 18-Sep-2024

Summary

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Official Symbol
ATR
Official Full Name
Ataxia telangiectasia-mutated and RAD3-like protein
Primary source
TAIR:AT5G40820
Locus tag
AT5G40820
See related
Araport:AT5G40820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED; ATATR; Ataxia telangiectasia-mutated and RAD3-related; ATRAD3; MHK7.5; MHK7_5
Summary
Encodes a Arabidopsis ortholog of the ATR protein kinase that is involved in a wide range of responses to DNA damage and plays a central role in cell-cycle regulation. Dominant loss of function alleles identified as suppressors of ALS also exhibit increased tolerance to aluminum. This may be due to the inhibition of terminal differentiation of the root apex upon exposure to Al.
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Genomic context

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See ATR in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (16342728..16353898, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome C1 family Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Rad21/Rec8-like family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aluminum-dependent root-growth inhibition in Arabidopsis results from AtATR-regulated cell-cycle arrest. Rounds MA, et al. Curr Biol, 2008 Oct 14. PMID 18835170
  2. Distinct roles of the ATR kinase and the Mre11-Rad50-Nbs1 complex in the maintenance of chromosomal stability in Arabidopsis. Amiard S, et al. Plant Cell, 2010 Sep. PMID 20876831, Free PMC Article
  3. A stable RNA G-quadruplex within the 5'-UTR of Arabidopsis thaliana ATR mRNA inhibits translation. Kwok CK, et al. Biochem J, 2015 Apr 1. PMID 25793418
  4. The Arabidopsis cell cycle checkpoint regulators TANMEI/ALT2 and ATR mediate the active process of aluminum-dependent root growth inhibition. Nezames CD, et al. Plant Cell, 2012 Feb. PMID 22345493, Free PMC Article
  5. Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Fitzgerald MS, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611295, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.
    Title: ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.
  2. Protein kinase ATR inhibits E3 ubiquitin ligase CRL4[PRL1] to stabilize ribonucleotide reductase in response to replication stress.
    Title: Protein kinase ATR inhibits E3 ubiquitin ligase CRL4(PRL1) to stabilize ribonucleotide reductase in response to replication stress.
  3. The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
    Title: The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
  4. The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.
    Title: The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response.
  5. Mutant ATR and ATM seeds are highly resistant to aging, establishing ATM and ATR as determinants of seed viability.
    Title: DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds.
  6. ATR function together with SOG1 and ALT2 to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.
    Title: Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
  7. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.
    Title: A stable RNA G-quadruplex within the 5'-UTR of Arabidopsis thaliana ATR mRNA inhibits translation.
  8. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.
    Title: ATR and MKP1 play distinct roles in response to UV-B stress in Arabidopsis.
  9. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
    Title: ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.
  10. TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.
    Title: The Arabidopsis cell cycle checkpoint regulators TANMEI/ALT2 and ATR mediate the active process of aluminum-dependent root growth inhibition.
Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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NM_001344355.1
NM_001344356.1
NM_001344357.1
NM_123447.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal reproductive process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of chromosome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of telomere maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to aluminum ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within telomere maintenance in response to DNA damage TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Ataxia telangiectasia-mutated and RAD3-like protein
NP_198898.2
  • Ataxia telangiectasia-mutated and RAD3-related (ATR); FUNCTIONS IN: protein serine/threonine kinase activity, inositol or phosphatidylinositol kinase activity, binding, phosphotransferase activity, alcohol group as acceptor; INVOLVED IN: in 9 processes; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), UME (InterPro:IPR012993), Protein kinase-like domain (InterPro:IPR011009), PIK-related kinase, FAT (InterPro:IPR003151), Armadillo-type fold (InterPro:IPR016024), PIK-related kinase (InterPro:IPR014009), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), PIK-related kinase, FATC (InterPro:IPR003152); BEST Arabidopsis thaliana protein match is: ataxia-telangiectasia mutated (TAIR:AT3G48190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    16342728..16353898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123447.3 → NP_198898.2  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198898.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FKS4, Q9MAZ4
    UniProtKB/TrEMBL
    A0A654G6W9
    Conserved Domains (3) summary
    smart00802
    Location:1088 → 1194
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    COG5032
    Location:1692 → 2702
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00892
    Location:2363 → 2638
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins

  2. NM_001344356.1 → NP_001332643.1  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FKS4, Q9MAZ4
    UniProtKB/TrEMBL
    A0A654G6W9
    Conserved Domains (3) summary
    smart00802
    Location:1088 → 1194
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    COG5032
    Location:1692 → 2702
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00892
    Location:2363 → 2638
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins

  3. NM_001344355.1 → NP_001332644.1  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1R7T394, A0A654G6W9

  4. NM_001344357.1 → NP_001332642.1  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FKS4, Q9MAZ4
    UniProtKB/TrEMBL
    A0A654G6W9
    Conserved Domains (3) summary
    smart00802
    Location:1088 → 1194
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    COG5032
    Location:1692 → 2702
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd00892
    Location:2363 → 2638
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FKS4.2

Gene LinkOut

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