DES1 L-cysteine desulfhydrase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DES1
Official Full Name: L-cysteine desulfhydrase 1
Primary source: TAIR:AT5G28030
Locus tag: AT5G28030
See related: Araport:AT5G28030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F15F15.100; F15F15_100; L-cysteine desulfhydrase 1
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Genomic context

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See DES1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 11

Sequence:: Chromosome: 5; NC_003076.8 (10029632..10032962, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling.
Title: Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling.
Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure.
Title: Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure.
DES1 is required for abscisic acid (ABA)-dependent nitric oxide (NO) production
Title: Hydrogen sulfide generated by L-cysteine desulfhydrase acts upstream of nitric oxide to modulate abscisic acid-dependent stomatal closure.
Mutations of L-CYS DESULFHYDRASE 1 (DES1) impede H(2)S generation in the Arabidopsis cytosol and strongly affect plant metabolism.
Title: Cysteine-generated sulfide in the cytosol negatively regulates autophagy and modulates the transcriptional profile in Arabidopsis.
Mutation of DES1 leads to premature leaf senescence and significantly reduces the total cysteine desulfuration activity in leaves.
Title: An O-acetylserine(thiol)lyase homolog with L-cysteine desulfhydrase activity regulates cysteine homeostasis in Arabidopsis.
Binding of the C-terminus of serine acetyltransferase by acetylserine sulfhydrylase contributes a large portion of the total binding energy during formation of the plant cysteine synthase complex.
Title: Thermodynamics of the interaction between O-acetylserine sulfhydrylase and the C-terminus of serine acetyltransferase.

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Pathways from PubChem

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General gene information

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NM_122686.2

Supported by ESTs:

NM_203114.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables L-cysteine desulfhydrase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-cystine L-cysteine-lyase (deaminating)	IEA Inferred from Electronic Annotation more info
enables cystathionine gamma-lyase activity	IEA Inferred from Electronic Annotation more info
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
involved_in intracellular cysteine homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular cysteine homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stress response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: L-cysteine desulfhydrase 1

NP_198155.1

L-cysteine desulfhydrase 1 (DES1); FUNCTIONS IN: pyridoxal phosphate binding, cysteine synthase activity, catalytic activity; INVOLVED IN: cysteine biosynthetic process from serine, cysteine biosynthetic process, metabolic process; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, LP.02 two leaves visible, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: cysteine synthase D2 (TAIR:AT5G28020.6); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NP_974843.1

L-cysteine desulfhydrase 1 (DES1); FUNCTIONS IN: pyridoxal phosphate binding, cysteine synthase activity, catalytic activity; INVOLVED IN: cysteine biosynthetic process from serine, cysteine biosynthetic process, metabolic process; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, LP.02 two leaves visible, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site (InterPro:IPR001216), Cysteine synthase A (InterPro:IPR005859), Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Cysteine synthase K/M (InterPro:IPR005856); BEST Arabidopsis thaliana protein match is: cysteine synthase D2 (TAIR:AT5G28020.6); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

10029632..10032962 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001344055.1 → NP_001330587.1 L-cysteine desulfhydrase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4K5T2

UniProtKB/TrEMBL

A0A178UEA4
NM_001344053.1 → NP_001330586.1 L-cysteine desulfhydrase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BB98
NM_001344054.1 → NP_001330588.1 L-cysteine desulfhydrase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4K5T2

UniProtKB/TrEMBL

A0A178UEA4
NM_203114.2 → NP_974843.1 L-cysteine desulfhydrase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974843.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4K5T2

UniProtKB/TrEMBL

A0A178UEA4

Conserved Domains (2) summary

PLN02565
Location:7 → 323

PLN02565; cysteine synthase

PLN00011
Location:1 → 323

PLN00011; cysteine synthase
NM_122686.2 → NP_198155.1 L-cysteine desulfhydrase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198155.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4K5T2

UniProtKB/TrEMBL

A0A178UEA4

Conserved Domains (2) summary

PLN02565
Location:7 → 323

PLN02565; cysteine synthase

PLN00011
Location:1 → 323

PLN00011; cysteine synthase