U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IRE1-1 inositol requiring 1-1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832507, updated on 18-Sep-2024

Summary

Official Symbol
IRE1-1
Official Full Name
inositol requiring 1-1
Primary source
TAIR:AT5G24360
Locus tag
AT5G24360
See related
Araport:AT5G24360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA INOSITOL REQUIRING 1-1; ATIRE1-1; AtIRE1b; inositol requiring 1-1; IRE1B; K16H17.7; K16H17_7
Summary
IRE1A and IRE1B catalyze bZIP60 mRNA splicing, producing the active bZIP60 transcription factor.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IRE1-1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (8316388..8319981)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein kinase WNK (With No Lysine)-like protein Neighboring gene uncharacterized protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene YELLOW STRIPE like 2 Neighboring gene Ypt/Rab-GAP domain of gyp1p superfamily protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

NM_001203454.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inositol requiring 1-1
NP_001190382.1
  • inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1).
NP_001190383.1
  • inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1).
NP_568444.1
  • inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyrrolo-quinoline quinone beta-propeller repeat (InterPro:IPR018391), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    8316388..8319981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122344.5NP_568444.1  inositol requiring 1-1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568444.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93VJ2, Q94IG5, Q9FIN6
    UniProtKB/TrEMBL
    A0A178UD27, A0A5S9Y779
    Conserved Domains (4) summary
    cd09213
    Location:48392
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
    cd10422
    Location:749875
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:463744
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:457745
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001203453.2NP_001190382.1  inositol requiring 1-1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UD27, A0A5S9Y779, F4KH40
    Conserved Domains (4) summary
    cd09213
    Location:54398
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
    cd10422
    Location:755881
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:469750
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:463751
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001203454.1NP_001190383.1  inositol requiring 1-1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190383.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UD27, A0A5S9Y779, A0A654G3Y0, F4KH41
    Conserved Domains (4) summary
    cd09213
    Location:34378
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
    cd10422
    Location:735861
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:449730
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:443731
    PKc_like; Protein Kinases, catalytic domain