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ATXR6 TRITHORAX-RELATED PROTEIN 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832503, updated on 18-Sep-2024

Summary

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Official Symbol
ATXR6
Official Full Name
TRITHORAX-RELATED PROTEIN 6
Primary source
TAIR:AT5G24330
Locus tag
AT5G24330
See related
Araport:AT5G24330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS TRITHORAX-RELATED PROTEIN 6; MOP9.7; MOP9_7; SDG34; SET DOMAIN PROTEIN 34
Summary
Encodes a SET-domain protein, a H3K27 monomethyltransferases required for chromatin structure and gene silencing. Regulates heterochromatic DNA replication. Contains a PCNA-binding domain. ATXR6 accumulates preferentially during the late G1 or S phase, suggesting that it plays a role in cell-cycle regulation or progression.
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Genomic context

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See ATXR6 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (8295110..8297159, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene 3'-5' exonuclease domain-containing protein Neighboring gene neuroblastoma-amplified sequence protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis. Potok ME, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35027454, Free PMC Article
  2. ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle. Davarinejad H, et al. J Mol Biol, 2019 Mar 29. PMID 30826376
  3. Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator. Latrasse D, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23341037, Free PMC Article
  4. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Jacob Y, et al. Nature, 2010 Aug 19. PMID 20631708, Free PMC Article
  5. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Jacob Y, et al. Nat Struct Mol Biol, 2009 Jul. PMID 19503079, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.
    Title: The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.
  2. ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
    Title: ATXR5/6 Forms Alternative Protein Complexes with PCNA and the Nucleosome Core Particle.
  3. mutations in the homologous histone 3 lysine 27 (H3K27) monomethyltransferases, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, lead to re-replication of specific genomic locations
    Title: Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.
  4. These results indicate that ATXR5 and ATXR6 form a new class of H3K27 methyltransferases and that H3K27me1 represents a previously uncharacterized pathway required for transcriptional repression in Arabidopsis.
    Title: ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.
  5. ATXR5 and ARXR6 interact with proliferating cell nuclear antigen (PCNA) and are associated with a role in the cell cycle or DNA replication. [ATXR6]
    Title: Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_122341.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anther dehiscence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
TRITHORAX-RELATED PROTEIN 6
NP_197821.1
  • ARABIDOPSIS TRITHORAX-RELATED PROTEIN 6 (ATXR6); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (TAIR:AT5G09790.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    8295110..8297159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122341.3 → NP_197821.1  TRITHORAX-RELATED PROTEIN 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197821.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FNE9
    UniProtKB/TrEMBL
    A0A178UMD0, A0A5S9Y6V5
    Conserved Domains (2) summary
    cd15543
    Location:35 → 79
    PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
    cd10539
    Location:211 → 349
    SET_ATXR5_6-like; SET domain found in fungal protein lysine methyltransferase SET5 and similar protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FNE9.1

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