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STE14A S-isoprenylcysteine O-methyltransferase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832396, updated on 18-Sep-2024

Summary

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Official Symbol
STE14A
Official Full Name
S-isoprenylcysteine O-methyltransferase
Primary source
TAIR:AT5G23320
Locus tag
AT5G23320
See related
Araport:AT5G23320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ISOPRENYL CYSTEINE METHYLTRANSFERASE A; ATICMTA; ATPCM; ATSTE14; ATSTE14A; homolog of yeast STE14 A; ICMTA; ISOPRENYL CYSTEINE METHYLTRANSFERASE A; LPHA-CARBOXYL METHYLTRANSFERASE; MKD15.18; MKD15_18; PRENYLCYSTEINE ALPHA-CARBOXYL METHYLTRANSFERASE; STE14
Summary
Encodes a prenylcysteine alpha-carboxyl methyltransferase involved in methylation of isoprenylated proteins. This protein appears to have lower catalytic activity and a lower transcript expression level than the other ICMT present in Arabidopsis (At5g08335). Analysis of ICMT RNAi lines suggests that this protein may be involved in flower and stem development.
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Genomic context

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See STE14A in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (7852585..7853963)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene prefoldin 5 Neighboring gene pyrimidine d Neighboring gene Fe superoxide dismutase 3 Neighboring gene Nucleotidylyl transferase superfamily protein Neighboring gene RNI-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis. Huizinga DH, et al. Mol Plant, 2010 Jan. PMID 19969520, Free PMC Article
  2. Prenylcysteine alpha-carboxyl methyltransferase expression and function in Arabidopsis thaliana. Narasimha Chary S, et al. Plant J, 2002 Dec. PMID 12472689
  3. Identification and functional expression in yeast of a prenylcysteine alpha-carboxyl methyltransferase gene from Arabidopsis thaliana. Crowell DN, et al. Plant Mol Biol, 2001 Mar. PMID 11352465
  4. Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting. Bracha-Drori K, et al. Plant Physiol, 2008 Sep. PMID 18641086, Free PMC Article
  5. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observations support the hypothesis that the ABA hypersensitive phenotype of fcly plants is the result of FC accumulation and inhibition of ICMT.
    Title: Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.
  2. phenotype of RNAi lines is similar to farnesyltransferase beta-subunit mutant enhanced response to abscisic acid2 but is more subtle
    Title: Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables carboxyl-O-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within C-terminal protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within C-terminal protein methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within shoot system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
S-isoprenylcysteine O-methyltransferase
NP_197723.1
  • homolog of yeast STE14 A (STE14A); CONTAINS InterPro DOMAIN/s: Isoprenylcysteine carboxyl methyltransferase (InterPro:IPR007269); BEST Arabidopsis thaliana protein match is: Isoprenylcysteine carboxyl methyltransferase (ICMT) family (TAIR:AT5G08335.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7852585..7853963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343798.1 → NP_001330699.1  S-isoprenylcysteine O-methyltransferase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178ULE8, A0A1P8BBN6, A0A5S9Y6S3
    Conserved Domains (1) summary
    COG2020
    Location:41 → 221
    STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]

  2. NM_122238.2 → NP_197723.1  S-isoprenylcysteine O-methyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0MFH5, Q9FMW9
    UniProtKB/TrEMBL
    A0A178ULE8, A0A654G3P8
    Conserved Domains (1) summary
    COG2020
    Location:16 → 196
    STE14; Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FMW9.1

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