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HTB2 histone B2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832352, updated on 18-Sep-2024

Summary

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Official Symbol
HTB2
Official Full Name
histone B2
Primary source
TAIR:AT5G22880
Locus tag
AT5G22880
See related
Araport:AT5G22880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
H2B; histone B2; HISTONE H2B; MRN17.11; MRN17_11
Summary
Encodes a histone 2B (H2B) protein. This protein can be ubiquitinated in planta, and this modification depends on the HUB1 and HUB2 E3 ubiquitin ligases.
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Genomic context

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See HTB2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_003076.8 (7651868..7652714, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene uncharacterized protein Neighboring gene C2H2 and C2HC zinc fingers superfamily protein Neighboring gene cation/H+ exchanger 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis. Zhang L, et al. Commun Biol, 2021 Feb 15. PMID 33589721, Free PMC Article
  2. Histone H2B monoubiquitination is involved in regulating the dynamics of microtubules during the defense response to Verticillium dahliae toxins in Arabidopsis. Hu M, et al. Plant Physiol, 2014 Apr. PMID 24567190, Free PMC Article
  3. Histone H2B deubiquitination is required for transcriptional activation of FLOWERING LOCUS C and for proper control of flowering in Arabidopsis. Schmitz RJ, et al. Plant Physiol, 2009 Feb. PMID 19091875, Free PMC Article
  4. DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis. Nassrallah A, et al. Elife, 2018 Sep 7. PMID 30192741, Free PMC Article
  5. Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis. Zou B, et al. Plant Physiol, 2014 May. PMID 24664204, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis.
    Title: Function of histone H2B monoubiquitination in transcriptional regulation of auxin biosynthesis in Arabidopsis.
  2. DET1-DDB1-Associated-1 (DDA1) protein interacts with SGF11 in vivo, linking the DET1 complex to light-dependent ubiquitin-mediated proteolytic degradation of the deubiquitination module.
    Title: DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis.
  3. H2B monoubiquitination at the R gene locus regulates its expression.
    Title: Monoubiquitination of histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis.
  4. These findings provide direct evidence for H2B monoubiquitination as an important modification with regulatory roles in the defense against Verticillium dahliae toxins.
    Title: Histone H2B monoubiquitination is involved in regulating the dynamics of microtubules during the defense response to Verticillium dahliae toxins in Arabidopsis.
  5. Role of histone H2B deubiquitination in the activation of gene expression and the perturbation of histone H2B deubiquitination in the timing of the floral transition in Arabidopsis.
    Title: Histone H2B deubiquitination is required for transcriptional activation of FLOWERING LOCUS C and for proper control of flowering in Arabidopsis.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_122194.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
histone B2
NP_197679.1
  • histone B2 (HTB2); FUNCTIONS IN: DNA binding; INVOLVED IN: nucleosome assembly; LOCATED IN: nucleolus, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histone H2B (InterPro:IPR000558), Histone-fold (InterPro:IPR009072), Histone core (InterPro:IPR007125); BEST Arabidopsis thaliana protein match is: Histone superfamily protein (TAIR:AT3G45980.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7651868..7652714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122194.3 → NP_197679.1  histone B2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197679.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q96516, Q9FFC0
    UniProtKB/TrEMBL
    A0A178UDD3, A0A654G3H0, Q1H5F7
    Conserved Domains (1) summary
    smart00427
    Location:54 → 144
    H2B; Histone H2B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FFC0.3

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