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poly ADP-ribose polymerase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832308, updated on 18-Sep-2024

Summary

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Official Full Name
poly ADP-ribose polymerase 3
Primary source
TAIR:AT5G22470
Locus tag
AT5G22470
See related
Araport:AT5G22470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtPARP3; MQJ16.1; MQJ16_1; PARP3; Poly(ADP-Ribose) Polymerase 3
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Genomic context

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Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (7446962..7451049)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L1p/L10e family Neighboring gene spectrin beta chain, brain Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ZPR1 zinc-finger domain protein Neighboring gene O-acyltransferase (WSD1-like) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage. Gu Z, et al. BMC Plant Biol, 2019 Aug 19. PMID 31426748, Free PMC Article
  2. Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis. Pham PA, et al. Plant Mol Biol, 2015 Nov. PMID 26428915, Free PMC Article
  3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtPARP3 has lost poly (ADP-ribose) polymerase activity in plants and performs different functions from those of AtPARP1 and AtPARP2. AtPARP1, instead of AtPARP2, plays the predominant role in PAR synthesis in both seeds and seedlings.
    Title: New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage.
  2. PARP isoforms play non-redundant non-nuclear metabolic roles and that their function is highly important in rapidly growing tissues such as the shoot apical meristem, roots and seeds. [PARP3]
    Title: Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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NM_001343735.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
poly ADP-ribose polymerase 3
NP_001318618.1
  • NAD+ ADP-ribosyltransferases;NAD+ ADP-ribosyltransferases; FUNCTIONS IN: NAD+ ADP-ribosyltransferase activity; INVOLVED IN: protein amino acid ADP-ribosylation; LOCATED IN: intracellular, nucleus; CONTAINS InterPro DOMAIN/s: WGR (InterPro:IPR008893), Poly(ADP-ribose) polymerase, regulatory domain (InterPro:IPR004102), PADR1 (InterPro:IPR012982), Poly(ADP-ribose) polymerase, catalytic domain (InterPro:IPR012317), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: poly(ADP-ribose) polymerase 2 (TAIR:AT2G31320.1); Has 672 Blast hits to 662 proteins in 152 species: Archae - 0; Bacteria - 20; Metazoa - 347; Fungi - 74; Plants - 111; Viruses - 2; Other Eukaryotes - 118 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7446962..7451049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343735.1 → NP_001318618.1  poly ADP-ribose polymerase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K9W5, Q8GXP3, Q9FK91
    UniProtKB/TrEMBL
    A0A2H1ZE65
Nucleotide Protein
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