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AIP2 RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832215, updated on 18-Sep-2024

Summary

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Official Symbol
AIP2
Official Full Name
RING/U-box superfamily protein
Primary source
TAIR:AT5G20910
Locus tag
AT5G20910
See related
Araport:AT5G20910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ABI3-interacting protein 2; F22D1.80; F22D1_80
Summary
Encodes an E3 ligase that can interact with and polyubiquitinate ABI3 in vitro. AIP2 likely negatively regulates ABA signaling by targeting ABI3 for post-translational destruction.
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Genomic context

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See AIP2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (7092512..7094503, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene TCP-1/cpn60 chaperonin family protein Neighboring gene jasmonate-zim-domain protein 12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene eukaryotic translation initiation factor 2 beta subunit Neighboring gene Protein kinase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation. Zhang X, et al. Genes Dev, 2005 Jul 1. PMID 15998807, Free PMC Article
  2. Interactions of the developmental regulator ABI3 with proteins identified from developing Arabidopsis seeds. Kurup S, et al. Plant J, 2000 Jan. PMID 10743655
  3. Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis. Stone SL, et al. Plant Physiol, 2005 Jan. PMID 15644464, Free PMC Article
  4. Analysis of the Arabidopsis nuclear proteome and its response to cold stress. Bae MS, et al. Plant J, 2003 Dec. PMID 14617066
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_122099.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RING/U-box superfamily protein
NP_197591.1
  • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT5G15820.1); Has 9587 Blast hits to 9565 proteins in 281 species: Archae - 0; Bacteria - 0; Metazoa - 2561; Fungi - 845; Plants - 4808; Viruses - 65; Other Eukaryotes - 1308 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7092512..7094503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122099.4 → NP_197591.1  RING/U-box superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197591.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXD3, Q9M4B6
    UniProtKB/TrEMBL
    A0A178URR2, A0A5S9Y6E8, A0A654G346
    Conserved Domains (2) summary
    cd00162
    Location:230 → 270
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    cl17238
    Location:229 → 271
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RXD3.1

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