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SMG7 Telomerase activating protein Est1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832060, updated on 18-Sep-2024

Summary

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Official Symbol
SMG7
Official Full Name
Telomerase activating protein Est1
Primary source
TAIR:AT5G19400
Locus tag
AT5G19400
See related
Araport:AT5G19400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F7K24.150; F7K24_150
Summary
Encodes SMG7, a protein that possesses an evolutionarily conserved EST1 domain and exhibits strong homology to human SMG6 (EST1A) and SMG7 (EST1C) proteins. SMG7 plays an evolutionarily conserved role in nonsense-mediated RNA decay (NMD). Required for exit from meiosis. Hypomorphic smg7 alleles render mutant plants sterile by causing an unusual cell-cycle arrest in anaphase II that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. Disruption of SMG7 causes embryonic lethality.
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Genomic context

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See SMG7 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (6539926..6545081)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene CRT (chloroquine-resistance transporter)-like transporter 1 Neighboring gene Rho GTPase activation protein (RhoGAP) with PH domain-containing protein Neighboring gene ABC-2 type transporter family protein Neighboring gene Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis. Capitao C, et al. PLoS Genet, 2021 Sep. PMID 34591845, Free PMC Article
  2. Arabidopsis SMG7 protein is required for exit from meiosis. Riehs N, et al. J Cell Sci, 2008 Jul 1. PMID 18544632
  3. The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions. Matsui H, et al. PLoS Genet, 2017 Oct. PMID 29073135, Free PMC Article
  4. Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay. Kerényi F, et al. Plant J, 2013 Dec. PMID 24118551
  5. The late steps of plant nonsense-mediated mRNA decay. Mérai Z, et al. Plant J, 2013 Jan. PMID 22974464

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.
    Title: A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.
  2. PSIG1 interacts with SMG7, which plays a role in nonsense-mediated RNA decay (NMD), and the smg7-4 mutant allele mimics the cell death phenotype of the psig1 mutants.
    Title: The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions.
  3. Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2)
    Title: Meiotic progression in Arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM.
  4. Data indicates that SMG7 counteracts cyclin-dependent kinase (CDK) activity at the end of meiosis, and reveals a novel link between SMG7 and regulation of the meiotic cell cycle. [SMG7]
    Title: Arabidopsis SMG7 protein is required for exit from meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001203408.1
NM_121945.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Telomerase activating protein Est1
NP_001190336.1
  • SMG7; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: meiosis, spindle assembly involved in meiosis, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2).
NP_001190337.1
  • SMG7; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: meiosis, spindle assembly involved in meiosis, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2).
NP_197441.3
  • SMG7; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2); Has 648 Blast hits to 623 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 367; Fungi - 169; Plants - 90; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    6539926..6545081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343597.1 → NP_001330788.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BBV1, A0A654G344

  2. NM_001343598.1 → NP_001330789.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BBV1, A0A654G344

  3. NM_001203407.2 → NP_001190336.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9QM73
    UniProtKB/TrEMBL
    A0A654G344
    Conserved Domains (2) summary
    pfam10373
    Location:203 → 533
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:66 → 189
    EST1; Telomerase activating protein Est1

  4. NM_121945.3 → NP_197441.3  Telomerase activating protein Est1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197441.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9QM73
    UniProtKB/TrEMBL
    A0A654G344
    Conserved Domains (2) summary
    pfam10373
    Location:203 → 533
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:66 → 189
    EST1; Telomerase activating protein Est1

  5. NM_001203408.1 → NP_001190337.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9QM73
    UniProtKB/TrEMBL
    A0A654G344
    Conserved Domains (2) summary
    pfam10373
    Location:203 → 533
    EST1_DNA_bind; Est1 DNA/RNA binding domain
    pfam10374
    Location:66 → 189
    EST1; Telomerase activating protein Est1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A9QM73.1

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