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Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832059, updated on 18-Sep-2024

Summary

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Official Full Name
Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
Primary source
TAIR:AT5G19390
Locus tag
AT5G19390
See related
Araport:AT5G19390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F7K24.140; F7K24_140
Summary
Encodes a protein with similarity to REN1, a Rho GTPase activating protein.
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Genomic context

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Location:
chromosome: 5
Exon count:
22
Sequence:
Chromosome: 5; NC_003076.8 (6531529..6538557)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene rhodanese-like domain-containing protein / PPIC-type PPIASE domain-containing protein Neighboring gene CRT (chloroquine-resistance transporter)-like transporter 1 Neighboring gene Telomerase activating protein Est1 Neighboring gene ABC-2 type transporter family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Putative RopGAPs impact division plane selection and interact with kinesin-12 POK1. Stöckle D, et al. Nat Plants, 2016 Aug 8. PMID 27501519
  2. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Hwang JU, et al. Curr Biol, 2008 Dec 23. PMID 19108776, Free PMC Article
  3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
  4. New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy. Peltier JB, et al. J Biol Chem, 2004 Nov 19. PMID 15322131
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

General gene information

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NM_001036827.1
NM_001036828.2
NM_121944.3
NM_180711.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell plate formation involved in plant-type cell wall biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with preprophase band IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
NP_001031904.1
  • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.2); Has 4537 Blast hits to 4371 proteins in 246 species: Archae - 4; Bacteria - 47; Metazoa - 3286; Fungi - 432; Plants - 222; Viruses - 0; Other Eukaryotes - 546 (source: NCBI BLink).
NP_001031905.1
  • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.2); Has 4185 Blast hits to 4168 proteins in 202 species: Archae - 0; Bacteria - 9; Metazoa - 3193; Fungi - 416; Plants - 210; Viruses - 0; Other Eukaryotes - 357 (source: NCBI BLink).
NP_197440.2
  • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_851042.2
  • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.1); Has 4617 Blast hits to 4464 proteins in 264 species: Archae - 6; Bacteria - 65; Metazoa - 3342; Fungi - 447; Plants - 223; Viruses - 0; Other Eukaryotes - 534 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    6531529..6538557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121944.3 → NP_197440.2  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197440.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFY3, F4K143, Q3E9B9, Q8RWQ4
    UniProtKB/TrEMBL
    A0A178UH09
    Conserved Domains (4) summary
    smart00233
    Location:19 → 125
    PH; Pleckstrin homology domain
    pfam00169
    Location:19 → 125
    PH; PH domain
    pfam00620
    Location:176 → 313
    RhoGAP; RhoGAP domain
    pfam14389
    Location:610 → 689
    Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

  2. NM_180711.2 → NP_851042.2  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851042.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFY3, F4K143, Q3E9B9, Q8RWQ4
    UniProtKB/TrEMBL
    A0A178UH09
    Conserved Domains (4) summary
    smart00233
    Location:19 → 125
    PH; Pleckstrin homology domain
    pfam00169
    Location:19 → 125
    PH; PH domain
    pfam00620
    Location:176 → 313
    RhoGAP; RhoGAP domain
    pfam14389
    Location:610 → 689
    Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

  3. NM_001036827.1 → NP_001031904.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UH09, F4K142
    Conserved Domains (4) summary
    smart00233
    Location:19 → 125
    PH; Pleckstrin homology domain
    pfam00169
    Location:19 → 125
    PH; PH domain
    pfam00620
    Location:176 → 313
    RhoGAP; RhoGAP domain
    pfam14389
    Location:610 → 689
    Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

  4. NM_001036828.2 → NP_001031905.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UH09
    Conserved Domains (4) summary
    smart00233
    Location:19 → 125
    PH; Pleckstrin homology domain
    pfam00169
    Location:19 → 125
    PH; PH domain
    pfam00620
    Location:176 → 313
    RhoGAP; RhoGAP domain
    pfam14389
    Location:610 → 689
    Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RWQ4.1

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