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APY2 apyrase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831946, updated on 18-Sep-2024

Summary

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Official Symbol
APY2
Official Full Name
apyrase 2
Primary source
TAIR:AT5G18280
Locus tag
AT5G18280
See related
Araport:AT5G18280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
APYRASE; apyrase 2; ATAPY2; MRG7.24; MRG7_24
Summary
Encodes an enzyme with ATPase and ADPase activity (an apyrase) that when mutated in combination with ATAPY1 causes a complete inhibition of pollen germination.
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Genomic context

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See APY2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (6050514..6054386, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene NAC domain containing protein 87 Neighboring gene Aquaporin-like superfamily protein Neighboring gene ncRNA Neighboring gene NAC domain containing protein 88

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. APYRASE1/2 mediate red light-induced de-etiolation growth in Arabidopsis seedlings. Weeraratne G, et al. Plant Physiol, 2022 Jun 27. PMID 35357495, Free PMC Article
  2. Modulation of Root Skewing in Arabidopsis by Apyrases and Extracellular ATP. Yang X, et al. Plant Cell Physiol, 2015 Nov. PMID 26412783
  3. Apyrase suppression raises extracellular ATP levels and induces gene expression and cell wall changes characteristic of stress responses. Lim MH, et al. Plant Physiol, 2014 Apr. PMID 24550243, Free PMC Article
  4. Effects of chemical inhibitors and apyrase enzyme further document a role for apyrases and extracellular ATP in the opening and closing of stomates in Arabidopsis. Clark G, et al. Plant Signal Behav, 2013 Nov. PMID 23989340, Free PMC Article
  5. Role for apyrases in polar auxin transport in Arabidopsis. Liu X, et al. Plant Physiol, 2012 Dec. PMID 23071251, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APYRASE1/2 mediate red light-induced de-etiolation growth in Arabidopsis seedlings.
    Title: APYRASE1/2 mediate red light-induced de-etiolation growth in Arabidopsis seedlings.
  2. Study reports that APY1 and, to a lesser extent, APY2 help control root skewing, the right-slanted growth of roots, in Arabidopsis.
    Title: Modulation of Root Skewing in Arabidopsis by Apyrases and Extracellular ATP.
  3. low levels of apyrase chemical inhibitors can induce stomatal opening in the dark, while apyrase enzyme blocks abscissic acid-induced stomatal closure.
    Title: Effects of chemical inhibitors and apyrase enzyme further document a role for apyrases and extracellular ATP in the opening and closing of stomates in Arabidopsis.
  4. APY1, APY2, and extracellular ATP play important roles in the signaling steps that link biotic stresses to plant defense responses and growth changes.
    Title: Apyrase suppression raises extracellular ATP levels and induces gene expression and cell wall changes characteristic of stress responses.
  5. Suppression of APY1/APY2 expression results in a significant inhibition of polar auxin transport in Arabidopsis hypocotyls and roots.
    Title: Role for apyrases in polar auxin transport in Arabidopsis.
  6. AtAPY1 and AtAPY2 are Golgi-localized nucleotide diphosphatases and are likely to have roles in regulating UDP/GDP concentrations in the Golgi lumen.
    Title: AtAPY1 and AtAPY2 function as Golgi-localized nucleoside diphosphatases in Arabidopsis thaliana.
  7. Both short-term inhibition of ectoapyrase activity by polyclonal antibodies and long-term suppression of APY1 and APY2 transcript levels significantly disrupt normal stomatal behavior in light.
    Title: Extracellular nucleotides and apyrases regulate stomatal aperture in Arabidopsis.
  8. acts to reduce the concentration of extracellular nucleotides, highest expression in rapidly growing tissues and/or tissues that accumulate high auxin levels
    Title: Apyrases (nucleoside triphosphate-diphosphohydrolases) play a key role in growth control in Arabidopsis.
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General gene information

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NM_121833.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
  
enables nucleoside diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within pollen germination IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi medial cisterna HDA PubMed 
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in endosome HDA PubMed 
located_in trans-Golgi network HDA PubMed 

General protein information

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Preferred Names
apyrase 2
NP_197329.5
  • apyrase 2 (APY2); CONTAINS InterPro DOMAIN/s: Nucleoside phosphatase GDA1/CD39 (InterPro:IPR000407); BEST Arabidopsis thaliana protein match is: apyrase 1 (TAIR:AT3G04080.1); Has 1437 Blast hits to 1429 proteins in 222 species: Archae - 0; Bacteria - 35; Metazoa - 609; Fungi - 299; Plants - 361; Viruses - 0; Other Eukaryotes - 133 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    6050514..6054386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121833.7 → NP_197329.5  apyrase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JWK7, I1VCB1, Q8L704, Q9M7B3, Q9SPM5
    UniProtKB/TrEMBL
    A0A178U9X1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SPM5.1

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