OFP1 ovate family protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: OFP1
Official Full Name: ovate family protein 1
Primary source: TAIR:AT5G01840
Locus tag: AT5G01840
See related: Araport:AT5G01840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA OVATE FAMILY PROTEIN 1; ATOFP1; ovate family protein 1; T20L15.110; T20L15_110
Summary: Encodes a member of the plant specific ovate protein family. Members of this family have been shown to bind to KNOX and BELL- like TALE class homeodomain proteins. This interaction may mediate relocalization of the TALE homeodomain from the nucleus to the cytoplasm. Functions as a transcriptional repressor that suppresses cell elongation.
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Genomic context

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See OFP1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 1

Sequence:: Chromosome: 5; NC_003076.8 (324428..325678)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results support our assumption that, by interacting with OFP1, BLH3 forms a functional protein complex that controls timing of progression from vegetative to reproductive phase.
Title: Ovate family protein1 interaction with BLH3 regulates transition timing from vegetative to reproductive phase in Arabidopsis.
This study shows that OFP1 and OFP4 enhance the repression activity of BLH6, supporting a role for these OFPs as components of a putative multi-protein transcription regulatory complex containing BLH6 and KNAT7.
Title: A role for OVATE FAMILY PROTEIN1 (OFP1) and OFP4 in a BLH6-KNAT7 multi-protein complex regulating secondary cell wall formation in Arabidopsis thaliana.
AtOFP1 is a DNA binding protein that can interact with AtKu70 in DNA double-strand break repair.
Title: Ovate family protein 1 as a plant Ku70 interacting protein involving in DNA double-strand break repair.
an active transcriptional repressor that has a role in regulating cell elongation in plants.
Title: Arabidopsis Ovate Family Protein 1 is a transcriptional repressor that suppresses cell elongation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120262.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ovate family protein 1

NP_195804.1

ovate family protein 1 (OFP1); FUNCTIONS IN: protein binding, transcription repressor activity; INVOLVED IN: N-terminal protein myristoylation, regulation of unidimensional cell growth; LOCATED IN: nucleolus, cytoskeleton; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF623 (InterPro:IPR006458); BEST Arabidopsis thaliana protein match is: ovate family protein 3 (TAIR:AT5G58360.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

324428..325678

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120262.3 → NP_195804.1 ovate family protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195804.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LZW2

UniProtKB/TrEMBL

A0A5S9Y0U6, A0A654FXG6

Conserved Domains (2) summary

pfam04844
Location:206 → 263

Ovate; Transcriptional repressor, ovate

pfam13724
Location:1 → 44

DNA_binding_2; DNA-binding domain