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CTR1 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831748, updated on 18-Sep-2024

Summary

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Official Symbol
CTR1
Official Full Name
Protein kinase superfamily protein
Primary source
TAIR:AT5G03730
Locus tag
AT5G03730
See related
Araport:AT5G03730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtCTR1; CONSTITUTIVE TRIPLE RESPONSE 1; F17C15.150; F17C15_150; SERINE/THREONINE-PROTEIN KINASE CTR1; SIS1; SUGAR-INSENSITIVE 1
Summary
Homologous to the RAF family of serine/threonine protein kinases. Negative regulator in the ethylene signal transduction pathway. Interacts with the putative ethylene receptors ETR1 and ERS. Constitutively expressed.
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Genomic context

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See CTR1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (974360..979849, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene replication factor C large subunit Neighboring gene heat shock transcription factor A3 Neighboring gene histone deacetylase 2C Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases. Kieber JJ, et al. Cell, 1993 Feb 12. PMID 8431946
  2. The sugar-insensitive1 (sis1) mutant of Arabidopsis is allelic to ctr1. Gibson SI, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162499
  3. Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis. Xie LJ, et al. PLoS Genet, 2015 Mar. PMID 25822663, Free PMC Article
  4. The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes. Achard P, et al. Proc Natl Acad Sci U S A, 2007 Apr 10. PMID 17389366, Free PMC Article
  5. Phosphatidic acid binds to and inhibits the activity of Arabidopsis CTR1. Testerink C, et al. J Exp Bot, 2007. PMID 18000017

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.
    Title: The SALT OVERLY SENSITIVE 2-CONSTITUTIVE TRIPLE RESPONSE1 module coordinates plant growth and salt tolerance in Arabidopsis.
  2. Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
    Title: Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 mutants - A dissection of molecular mechanisms involved in acclimation.
  3. Epistatic interaction of CTR1 and ALF3 genes in Arabidopsis roots has been reported.
    Title: Features inheritance of root system Arabidopsis thaliana (L.) Heynh. the interaction of genes CTR1 AND ALF3, NPH4 and IAR2.
  4. Suc sustains rhythms in the dark by stabilizing GI protein, dependent on the F-box protein ZEITLUPE, and implicate CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a negative regulator of ethylene signaling.
    Title: Sucrose and Ethylene Signaling Interact to Modulate the Circadian Clock.
  5. the roles of CTR1-related proteins appear to have functionally diversified during land-plant evolution.
    Title: An Ancestral Role for CONSTITUTIVE TRIPLE RESPONSE1 Proteins in Both Ethylene and Abscisic Acid Signaling.
  6. The dark submergence-sensitive phenotypes of loh mutants were rescued by a ctr1-1 mutation. Thus, our findings demonstrate that unsaturation of VLC ceramides is a protective strategy for hypoxic tolerance in Arabidopsis
    Title: Unsaturation of very-long-chain ceramides protects plant from hypoxia-induced damages by modulating ethylene signaling in Arabidopsis.
  7. Ethylene (ET) affects auxin signaling through the central regulator CTR1 and that fungal-derived compounds, such as indole-3-acetic acid and indole-3-acetaldehyde, induce MPK6 activity.
    Title: Mitogen-Activated Protein Kinase 6 and Ethylene and Auxin Signaling Pathways Are Involved in Arabidopsis Root-System Architecture Alterations by Trichoderma atroviride.
  8. Ethylene receptor/CTR1 signaling is regulated by ethylene in Arabidopsis thaliana
    Title: Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana.
  9. Protein phosphorylation plays a key role in ethylene signaling, which is mediated by the activities of ethylene receptors, CTR1, and RCN1.
    Title: Stable isotope metabolic labeling-based quantitative phosphoproteomic analysis of Arabidopsis mutants reveals ethylene-regulated time-dependent phosphoproteins and putative substrates of constitutive triple response 1 kinase.
  10. Genetic studies unveiled the existence of are1-1 mutation in the ctr1-1 mutant, as a second-site modifier which confers root-specific ethylene-resistance.
    Title: Genetic identification of a second site modifier of ctr1-1 that controls ethylene-responsive and gravitropic root growth in Arabidopsis thaliana.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_120454.4
NM_180429.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity HDA PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within gibberellin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
acts_upstream_of_or_within regulation of post-embryonic root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to ethylene IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to fructose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to sucrose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sugar mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Protein kinase superfamily protein
NP_195993.1
  • CONSTITUTIVE TRIPLE RESPONSE 1 (CTR1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT4G24480.1); Has 126606 Blast hits to 124675 proteins in 4966 species: Archae - 112; Bacteria - 13843; Metazoa - 48138; Fungi - 11278; Plants - 33351; Viruses - 509; Other Eukaryotes - 19375 (source: NCBI BLink).
NP_850760.1
  • CONSTITUTIVE TRIPLE RESPONSE 1 (CTR1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT4G24480.1); Has 126606 Blast hits to 124675 proteins in 4966 species: Archae - 112; Bacteria - 13843; Metazoa - 48138; Fungi - 11278; Plants - 33351; Viruses - 509; Other Eukaryotes - 19375 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    974360..979849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180429.4 → NP_850760.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850760.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05609
    UniProtKB/TrEMBL
    A0A178UAE5, A0A5S9Y1U0, Q0WUI6
    Conserved Domains (3) summary
    smart00219
    Location:551 → 805
    TyrKc; Tyrosine kinase, catalytic domain
    cd13999
    Location:557 → 805
    STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
    pfam14381
    Location:208 → 413
    EDR1; Ethylene-responsive protein kinase Le-CTR1

  2. NM_120454.4 → NP_195993.1  Protein kinase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05609
    UniProtKB/TrEMBL
    A0A178UAE5, A0A5S9Y1U0, Q0WUI6
    Conserved Domains (3) summary
    smart00219
    Location:551 → 805
    TyrKc; Tyrosine kinase, catalytic domain
    cd13999
    Location:557 → 805
    STKc_MAP3K-like; Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases
    pfam14381
    Location:208 → 413
    EDR1; Ethylene-responsive protein kinase Le-CTR1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05609.1

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