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RIC4 ROP-interactive CRIB motif-containing protein 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831510, updated on 18-Sep-2024

Summary

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Official Symbol
RIC4
Official Full Name
ROP-interactive CRIB motif-containing protein 4
Primary source
TAIR:AT5G16490
Locus tag
AT5G16490
See related
Araport:AT5G16490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MQK4.23; MQK4_23; ROP-interactive CRIB motif-containing protein 4
Summary
encodes a member of a novel protein family that contains contain a CRIB (for Cdc42/Rac-interactive binding) motif required for their specific interaction with GTP-bound Rop1 (plant-specific Rho GTPase). It interacts with Rop1 and is involved in pollen tube growth and function, and exocytosis in the pollen tube tip. Protein most similar to RIC2 (family subgroup V). Gene is expressed in all tissues examined.Interacts with ROP2 during pavement cell morphogenesis and with ROP1 to promote apical F-actin assembly.
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Genomic context

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See RIC4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (5384250..5385230, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Phosphotyrosine protein phosphatases superfamily protein Neighboring gene RNA-directed DNA polymerase (reverse transcriptase)-related family protein Neighboring gene Protein kinase superfamily protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. Gu Y, et al. J Cell Biol, 2005 Apr 11. PMID 15824136, Free PMC Article
  2. Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Fu Y, et al. Cell, 2005 Mar 11. PMID 15766531
  3. Rho-GTPase-dependent filamentous actin dynamics coordinate vesicle targeting and exocytosis during tip growth. Lee YJ, et al. J Cell Biol, 2008 Jun 30. PMID 18591430, Free PMC Article
  4. A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-containing proteins that act as Rop GTPase targets. Wu G, et al. Plant Cell, 2001 Dec. PMID 11752391, Free PMC Article
  5. An integrative approach to the identification of Arabidopsis and rice genes involved in xylan and secondary wall development. Oikawa A, et al. PLoS One, 2010 Nov 23. PMID 21124849, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_121654.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellulose microfibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of vesicle localization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pollen tube growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ROP-interactive CRIB motif-containing protein 4
NP_197153.1
  • ROP-interactive CRIB motif-containing protein 4 (RIC4); CONTAINS InterPro DOMAIN/s: PAK-box/P21-Rho-binding (InterPro:IPR000095); BEST Arabidopsis thaliana protein match is: ROP-interactive CRIB motif-containing protein 10 (TAIR:AT4G04900.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    5384250..5385230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121654.3 → NP_197153.1  ROP-interactive CRIB motif-containing protein 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197153.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FFD5
    UniProtKB/TrEMBL
    A0A178UTG6, A0A5S9Y4P0
    Conserved Domains (1) summary
    cd00132
    Location:97 → 133
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FFD5.1

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