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RHL2 Spo11/DNA topoisomerase VI, subunit A protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831314, updated on 18-Sep-2024

Summary

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Official Symbol
RHL2
Official Full Name
Spo11/DNA topoisomerase VI, subunit A protein
Primary source
TAIR:AT5G02820
Locus tag
AT5G02820
See related
Araport:AT5G02820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BIN5; BRASSINOSTEROID INSENSITIVE 5; F9G14.130; F9G14_130; ROOT HAIRLESS 2; SPO11-3
Summary
Involved in the patterning and shape of leaf trichomes. Encodes the DNA topoisomerase VI SPO11-3, involved in endoreduplication
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Genomic context

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See RHL2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_003076.8 (642554..644394)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo-response regulator 7 Neighboring gene tRNA-Ser Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene LHY/CCA1-like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integration of stress-related and reactive oxygen species-mediated signals by Topoisomerase VI in Arabidopsis thaliana. Simková K, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988090, Free PMC Article
  2. DNA topoisomerase VI is essential for endoreduplication in Arabidopsis. Sugimoto-Shirasu K, et al. Curr Biol, 2002 Oct 15. PMID 12401175
  3. Molecular characterization of homologues of both subunits A (SPO11) and B of the archaebacterial topoisomerase 6 in plants. Hartung F, et al. Gene, 2001 Jun 13. PMID 11410368
  4. MIDGET unravels functions of the Arabidopsis topoisomerase VI complex in DNA endoreduplication, chromatin condensation, and transcriptional silencing. Kirik V, et al. Plant Cell, 2007 Oct. PMID 17951446, Free PMC Article
  5. RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth. Sugimoto-Shirasu K, et al. Proc Natl Acad Sci U S A, 2005 Dec 20. PMID 16339310, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Topo VI acts as an integrator of multiple signals generated by reactive oxygen species formed under adverse environmental conditions.
    Title: Integration of stress-related and reactive oxygen species-mediated signals by Topoisomerase VI in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_120360.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within plant epidermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Spo11/DNA topoisomerase VI, subunit A protein
NP_195902.1
  • ROOT HAIRLESS 2 (RHL2); CONTAINS InterPro DOMAIN/s: Spo11/DNA topoisomerase VI, subunit A, N-terminal (InterPro:IPR013049), DNA topoisomerase VI, subunit A (InterPro:IPR004085), Spo11/DNA topoisomerase VI, subunit A (InterPro:IPR002815); BEST Arabidopsis thaliana protein match is: Spo11/DNA topoisomerase VI, subunit A protein (TAIR:AT3G13170.1); Has 936 Blast hits to 932 proteins in 314 species: Archae - 223; Bacteria - 16; Metazoa - 170; Fungi - 119; Plants - 152; Viruses - 0; Other Eukaryotes - 256 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    642554..644394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120360.4 → NP_195902.1  Spo11/DNA topoisomerase VI, subunit A protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LZ03
    UniProtKB/TrEMBL
    A0A178UQD3, A0A5S9Y1I0
    Conserved Domains (1) summary
    PRK04342
    Location:91 → 427
    PRK04342; DNA topoisomerase IV subunit A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LZ03.1

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