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SMT1 sterol methyltransferase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831216, updated on 18-Sep-2024

Summary

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Official Symbol
SMT1
Official Full Name
sterol methyltransferase 1
Primary source
TAIR:AT5G13710
Locus tag
AT5G13710
See related
Araport:AT5G13710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CEPHALOPOD; CPH; MSH12.18; MSH12_18; SAM:CYCLOARTENOL-C24-METHYLTRANSFERASE; sterol methyltransferase 1
Summary
SMT1 controls the level of cholesterol in plants
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Genomic context

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See SMT1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Sequence:
Chromosome: 5; NC_003076.8 (4423555..4427324, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene IKI3 family protein Neighboring gene alpha-N-acetylglucosaminidase family / NAGLU family Neighboring gene polyamine oxidase 1 Neighboring gene Uncharacterized protein family (UPF0114) Neighboring gene sigma factor 4 Neighboring gene zinc induced facilitator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sterol methyltransferase 1 controls the level of cholesterol in plants. Diener AC, et al. Plant Cell, 2000 Jun. PMID 10852933, Free PMC Article
  2. The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products. Carland F, et al. Plant Physiol, 2010 Jun. PMID 20421456, Free PMC Article
  3. Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes. Cheng Z, et al. Plant Cell, 2003 Oct. PMID 14508009, Free PMC Article
  4. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article
  5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutants deficient in both SMT1 and SMT2 are embryo lethal.
    Title: The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001085110.1
NM_121374.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables sterol 24-C-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol 24-C-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sterol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasmodesma HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
sterol methyltransferase 1
NP_001078579.1
  • sterol methyltransferase 1 (SMT1); CONTAINS InterPro DOMAIN/s: Sterol methyltransferase C-terminal (InterPro:IPR013705), Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: sterol methyltransferase 3 (TAIR:AT1G76090.1); Has 12253 Blast hits to 12250 proteins in 2286 species: Archae - 352; Bacteria - 8578; Metazoa - 91; Fungi - 457; Plants - 727; Viruses - 0; Other Eukaryotes - 2048 (source: NCBI BLink).
NP_196875.1
  • sterol methyltransferase 1 (SMT1); FUNCTIONS IN: sterol 24-C-methyltransferase activity; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: vacuole; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol methyltransferase C-terminal (InterPro:IPR013705), Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: sterol methyltransferase 3 (TAIR:AT1G76090.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4423555..4427324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121374.4 → NP_196875.1  sterol methyltransferase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LKW1, Q9LM02
    UniProtKB/TrEMBL
    A0A5S9Y3U9, A0A654G0T6
    Conserved Domains (2) summary
    pfam08241
    Location:99 → 192
    Methyltransf_11; Methyltransferase domain
    pfam08498
    Location:271 → 335
    Sterol_MT_C; Sterol methyltransferase C-terminal

  2. NM_001085110.1 → NP_001078579.1  sterol methyltransferase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078579.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LKW1, Q9LM02
    UniProtKB/TrEMBL
    A0A5S9Y3U9, A0A654G0T6
    Conserved Domains (2) summary
    pfam08241
    Location:99 → 192
    Methyltransf_11; Methyltransferase domain
    pfam08498
    Location:271 → 335
    Sterol_MT_C; Sterol methyltransferase C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LM02.1

Gene LinkOut

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