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CLE40 CLAVATA3/ESR-RELATED 40 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831139, updated on 18-Sep-2024

Summary

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Official Symbol
CLE40
Official Full Name
CLAVATA3/ESR-RELATED 40
Primary source
TAIR:AT5G12990
Locus tag
AT5G12990
See related
Araport:AT5G12990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CLAVATA3/ESR-RELATED 40; T24H18.160; T24H18_160
Summary
Member of a large family of putative ligands homologous to the Clavata3 gene. Consists of a single exon.
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Genomic context

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See CLE40 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (4109234..4109784, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene proline-tRNA ligase (DUF1680) Neighboring gene Calcium-dependent lipid-binding (CaLB domain) plant phosphoribosyltransferase family protein Neighboring gene Cell differentiation, Rcd1-like protein Neighboring gene glucan synthase-like 12 Neighboring gene RNA helicase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CLE40 Signaling Regulates Root Stem Cell Fate. Berckmans B, et al. Plant Physiol, 2020 Apr. PMID 31806736, Free PMC Article
  2. Loss of CLE40, a protein functionally equivalent to the stem cell restricting signal CLV3, enhances root waving in Arabidopsis. Hobe M, et al. Dev Genes Evol, 2003 Aug. PMID 12743822
  3. Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis. Richards S, et al. J Exp Bot, 2015 Aug. PMID 26019259, Free PMC Article
  4. Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways. Schlegel J, et al. Elife, 2021 Oct 13. PMID 34643181, Free PMC Article
  5. The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway. Fiers M, et al. Plant Cell, 2005 Sep. PMID 16055633, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.
    Title: Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.
  2. CLE40 Signaling Regulates Root Stem Cell Fate.
    Title: CLE40 Signaling Regulates Root Stem Cell Fate.
  3. WOX5 signals from the quiescent centre to promote columella stem cell (CSC) fate, while CLE40 is secreted from the differentiated columella cells to promote differentiation.
    Title: Mathematical modelling of WOX5- and CLE40-mediated columella stem cell homeostasis in Arabidopsis.
  4. Data suggest that CLV3, CLE19 and CLE40 peptides represent the major active domain of the CLE proteins, which interact with an unknown cell identity-maintaining CLAVATA2 receptor complex in roots, leading to consumption of the root meristem.
    Title: The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables receptor serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell signaling involved in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of root meristem identity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phloem development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
CLAVATA3/ESR-RELATED 40
NP_196803.1
  • CLAVATA3/ESR-RELATED 40 (CLE40); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4109234..4109784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121302.2 → NP_196803.1  CLAVATA3/ESR-RELATED 40 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196803.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LXU0
    UniProtKB/TrEMBL
    A0A5S9Y481, A0A654G0L0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LXU0.1

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