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PRT6 proteolysis 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830916, updated on 18-Sep-2024

Summary

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Official Symbol
PRT6
Official Full Name
proteolysis 6
Primary source
TAIR:AT5G02310
Locus tag
AT5G02310
See related
Araport:AT5G02310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT5G02300; proteolysis 6; T1E22.70; T1E22_70
Summary
Encodes PROTEOLYSIS6 (PRT6), a component of the N-end rule pathway that targets protein degradation through the identity of the amino-terminal residue of specific protein substrates. Another component of the N-end rule pathway is arginyl-tRNA:protein arginyltransferase (ATE). Arabidopsis contains two ATE genes: At5g05700/ATE1, At3g11240/ATE2. PRT6 and ATE were shown to regulate seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination.
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Genomic context

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See PRT6 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Sequence:
Chromosome: 5; NC_003076.8 (473868..482942)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene non-intrinsic ABC protein 9 Neighboring gene SNARE-like superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene myb domain protein 3r-5 Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus. Garzón M, et al. FEBS Lett, 2007 Jul 10. PMID 17572409
  2. NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence. Castillo MC, et al. Plant Physiol, 2021 Dec 4. PMID 34618055, Free PMC Article
  3. The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development. Labandera AM, et al. New Phytol, 2021 Jan. PMID 32043277, Free PMC Article
  4. Distinct branches of the N-end rule pathway modulate the plant immune response. Vicente J, et al. New Phytol, 2019 Jan. PMID 30117535
  5. The CER3 wax biosynthetic gene from Arabidopsis thaliana is allelic to WAX2/YRE/FLP1. Rowland O, et al. FEBS Lett, 2007 Jul 24. PMID 17624331

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence.
    Title: NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence.
  2. The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.
    Title: The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.
  3. PRT6 control of germination and establishment, as exemplified by ABA and sugar sensitivity, as well as storage oil mobilization, occurs at least in part via transcription factors ABI3 and ABI5.
    Title: The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis.
  4. At5g02310 is not identical to CER3, a gene involved in establishment of a protective surface wax layer. At5g02310 has therefore been re-designated PROTEOLYSIS 6 (PRT6), in accordance with its ubiquitin ligase function.
    Title: PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus.
  5. CER3 is not At5g02310 and instead corresponds to WAX2/YRE/FLP1 (At5g57800), a gene of unknown function required for wax biosynthesis
    Title: The CER3 wax biosynthetic gene from Arabidopsis thaliana is allelic to WAX2/YRE/FLP1.
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General gene information

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NM_001342651.1
NM_120309.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in wax biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
proteolysis 6
NP_001318457.1
  • proteolysis 6 (PRT6); CONTAINS InterPro DOMAIN/s: Zinc finger, N-recognin, metazoa (InterPro:IPR013993), Zinc finger, N-recognin (InterPro:IPR003126); Has 1893 Blast hits to 778 proteins in 199 species: Archae - 0; Bacteria - 0; Metazoa - 939; Fungi - 577; Plants - 100; Viruses - 0; Other Eukaryotes - 277 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    473868..482942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001342652.1 → NP_001331954.1  proteolysis 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UMF0, A0A1P8BFH3

  2. NM_001342651.1 → NP_001318457.1  proteolysis 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4KCC2, Q96248, Q9LZ94, Q9LZ95
    UniProtKB/TrEMBL
    A0A178UMF0

  3. NM_120309.2 → NP_195851.2  proteolysis 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195851.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4KCC2, Q96248, Q9LZ94, Q9LZ95
    UniProtKB/TrEMBL
    A0A178UMF0
    Conserved Domains (1) summary
    pfam02207
    Location:121 → 187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4KCC2.1

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