AIL6 AINTEGUMENTA-like 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AIL6
Official Full Name: AINTEGUMENTA-like 6
Primary source: TAIR:AT5G10510
Locus tag: AT5G10510
See related: Araport:AT5G10510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AINTEGUMENTA-like 6; F12B17.140; F12B17_140; PLETHORA 3; PLT3
Summary: Encodes an AP2-domain transcription factor involved in root stem cell identity and root development. It is also required to maintain high levels of PIN1 expression at the periphery of the meristem and modulate local auxin production in the central region of the SAM which underlies phyllotactic transitions.
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Genomic context

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See AIL6 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 11

Sequence:: Chromosome: 5; NC_003076.8 (3315401..3320323)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AINTEGUMENTA and redundant AINTEGUMENTA-LIKE6 are required for bract outgrowth in Arabidopsis.
Title: AINTEGUMENTA and redundant AINTEGUMENTA-LIKE6 are required for bract outgrowth in Arabidopsis.
AINTEGUMENTA and AINTEGUMENTA-LIKE6 directly regulate floral homeotic, growth, and vascular development genes in young Arabidopsis flowers.
Title: AINTEGUMENTA and AINTEGUMENTA-LIKE6 directly regulate floral homeotic, growth, and vascular development genes in young Arabidopsis flowers.
This study characterized the effects of three PLETHORA (PLT) transcription factors, PLT3, PLT5, and PLT7, during lateral root outgrowth.
Title: PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth.
AIL6 regulates biological pathways that are critical for cell wall remodeling and defense.
Title: RNA-Seq Links the Transcription Factors AINTEGUMENTA and AINTEGUMENTA-LIKE6 to Cell Wall Remodeling and Plant Defense Pathways.
ANT and AIL6 directly induce LFY expression in response to auxin to promote the onset of flower formation.
Title: AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
The results presented here indicate that AIL6 intronic sequences serve as transcriptional enhancer elements.
Title: Intronic sequences are required for AINTEGUMENTA-LIKE6 expression in Arabidopsis flowers.
AIL genes exhibit unequal genetic redundancy with roles for AIL5, AIL6, and AIL7 only revealed in the absence of ANT function. AIL5, AIL6, and AIL7 act in a dose dependent manners in ant and other mutant backgrounds.
Title: AINTEGUMENTA-LIKE genes have partly overlapping functions with AINTEGUMENTA but make distinct contributions to Arabidopsis thaliana flower development.
PLT3, PLT5, and PLT7 additionally regulate and require the shoot-promoting factor CUP-SHAPED COTYLEDON2 (CUC2) to complete the shoot-formation program.
Title: PLETHORA Genes Control Regeneration by a Two-Step Mechanism.
PLT proteins are key regulators of PIN1 activity in control of phyllotaxis. PLT3, PLT5, and PLT7 are essential for normal phyllotaxis. [PLT3]
Title: Arabidopsis PLETHORA transcription factors control phyllotaxis.
In A. thaliana, three transcriptional regulators implicated in phyllotaxis, PLETHORA3 (PLT3), PLT5, and PLT7, are expressed in incipient lateral root primordia where they are required for primordium development and lateral root emergence.
Title: Phyllotaxis and rhizotaxis in Arabidopsis are modified by three PLETHORA transcription factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001343115.1

Supported by ESTs:

NM_001343118.1

Supported by ESTs:

NM_001343119.1

Supported by ESTs:

NM_121089.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within callus formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leaf phyllotactic patterning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within maintenance of shoot apical meristem identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phyllotactic patterning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of floral meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: AINTEGUMENTA-like 6

NP_001190279.1

AINTEGUMENTA-like 6 (AIL6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: AINTEGUMENTA-like 7 (TAIR:AT5G65510.1).

NP_001318528.1

AINTEGUMENTA-like 6 (AIL6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: AINTEGUMENTA-like 7 (TAIR:AT5G65510.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_196613.2

AINTEGUMENTA-like 6 (AIL6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: AINTEGUMENTA-like 7 (TAIR:AT5G65510.1); Has 34181 Blast hits to 11297 proteins in 411 species: Archae - 14; Bacteria - 43; Metazoa - 1028; Fungi - 1178; Plants - 6969; Viruses - 2; Other Eukaryotes - 24947 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

3315401..3320323

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001343116.1 → NP_001331270.1 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y3P3
NM_001343117.1 → NP_001331269.1 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDC1, A0A5S9Y3P3
NM_001203350.1 → NP_001190279.1 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190279.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y3P3, F4KGW7

Conserved Domains (2) summary

smart00380
Location:268 → 360

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs

cl00033
Location:390 → 454

AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...
NM_001343115.1 → NP_001318528.1 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q52QU2, Q6PQQ5, Q9LXA3

UniProtKB/TrEMBL

A0A2H1ZE66, A0A654G0C4
NM_001343118.1 → NP_001331268.1 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y3P3
NM_121089.3 → NP_196613.2 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196613.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9Y3P3, F4KGW9

Conserved Domains (2) summary

smart00380
Location:253 → 325

AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs

cl00033
Location:355 → 419

AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...
NM_001343119.1 → NP_001331267.1 AINTEGUMENTA-like 6 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDC1, A0A5S9Y3P3