GRF6 G-box regulating factor 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: GRF6
Official Full Name: G-box regulating factor 6
Primary source: TAIR:AT5G10450
Locus tag: AT5G10450
See related: Araport:AT5G10450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 14-3-3 PROTEIN G-BOX FACTOR14 LAMBDA; 14-3-3lambda; 14-3-3LAMBDA; AFT1; F12B17.200; F12B17_200; G-box regulating factor 6; GF14 LAMBDA
Summary: Encodes a member of the 14-3-3 gene family that is a lambda isoform (14-3-3lambda). Interacts with APX3 (ascorbate peroxidase) and AKR2, suggesting a role in mediating oxidative metabolism in stress response. This protein was shown to colocalize and interact with SERK1 by which it is phosphorylated. This protein is also reported to interact with the phosphorylated form of the BZR1 transcription factor involved in brassinosteroid signaling and may affect the nucleocytoplasmic shuttling of BZR1. Interacts with JAZ10.4 which lacks the Jas motif.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See GRF6 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (3283853..3286537, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that 14-3-3 lambda is required for actin depolymerizing factor 1 (ADF1) phosphorylation and subcellular localization.
Title: 14-3-3 λ protein interacts with ADF1 to regulate actin cytoskeleton dynamics in Arabidopsis.
The 14-3-3 lambda mutation impairs stomatal opening mediated by PHOT2.
Title: The role of a 14-3-3 protein in stomatal opening mediated by PHOT2 in Arabidopsis.
study suggest that GF14lambda may positively regulate the RPW8.2 resistance function and play a role in enhancing basal resistance in Arabidopsis.
Title: Arabidopsis 14-3-3 lambda is a positive regulator of RPW8-mediated disease resistance.
the 14-3-3 lambda (lambda) isoform from Arabidopsis. 14-3-3lambda and phot1 were found to colocalise and interact in vivo
Title: Interaction specificity of Arabidopsis 14-3-3 proteins with phototropin receptor kinases.
findings show that AtTPK1 (KCO1)interacts with 14-3-3 proteins (general regulating factors, GRFs); TPK1 and GRF6 co-localize at the vacuolar membrane
Title: TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

MASC_STS15414 (e-PCR)
- UniSTS:258800

Homology

Orthologs from OrthoDB

NM_001036791.2

Supported by ESTs:

NM_001203346.1

Supported by ESTs:

NM_001203347.1

Supported by ESTs:

NM_121083.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphorylated amino acid binding	TAS Traceable Author Statement more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to freezing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: G-box regulating factor 6

NP_001031868.1

G-box regulating factor 6 (GRF6); FUNCTIONS IN: protein phosphorylated amino acid binding; INVOLVED IN: brassinosteroid mediated signaling pathway, response to cadmium ion, defense response to bacterium, phosphorylation; LOCATED IN: cytosol, cell wall, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: general regulatory factor 8 (TAIR:AT5G65430.2); Has 2704 Blast hits to 2695 proteins in 386 species: Archae - 0; Bacteria - 0; Metazoa - 1262; Fungi - 303; Plants - 764; Viruses - 0; Other Eukaryotes - 375 (source: NCBI BLink).

NP_001190275.1

G-box regulating factor 6 (GRF6); CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: general regulatory factor 8 (TAIR:AT5G65430.3).

NP_001190276.1

G-box regulating factor 6 (GRF6); CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: general regulatory factor 8 (TAIR:AT5G65430.2).

NP_568229.1

G-box regulating factor 6 (GRF6); FUNCTIONS IN: protein phosphorylated amino acid binding; INVOLVED IN: brassinosteroid mediated signaling pathway, response to cadmium ion, defense response to bacterium, phosphorylation; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 14-3-3 protein (InterPro:IPR000308); BEST Arabidopsis thaliana protein match is: general regulatory factor 8 (TAIR:AT5G65430.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).