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GDH2 glutamate dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830635, updated on 18-Sep-2024

Summary

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Official Symbol
GDH2
Official Full Name
glutamate dehydrogenase 2
Primary source
TAIR:AT5G07440
Locus tag
AT5G07440
See related
Araport:AT5G07440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
glutamate dehydrogenase 2; GLUTAMATE DEHYDROGENASE 2; T2I1.150; T2I1_150
Summary
Encodes the beta-subunit of the glutamate dehydrogenase. The enzyme is almost exclusively found in the mitochondria of stem and leaf companion cells.
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Genomic context

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See GDH2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (2355759..2358241)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene miscRNA Neighboring gene cyclin p4;3 Neighboring gene peptidemethionine sulfoxide reductase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nitrogen recycling and remobilization are differentially controlled by leaf senescence and development stage in Arabidopsis under low nitrogen nutrition. Diaz C, et al. Plant Physiol, 2008 Jul. PMID 18467460, Free PMC Article
  2. Induction of Arabidopsis gdh2 gene expression during changes in redox state of the mitochondrial respiratory chain. Tarasenko VI, et al. Biochemistry (Mosc), 2009 Jan. PMID 19232048
  3. Characterization and expression of NAD(H)-dependent glutamate dehydrogenase genes in Arabidopsis. Turano FJ, et al. Plant Physiol, 1997 Apr. PMID 9112779, Free PMC Article
  4. Control of the synthesis and subcellular targeting of the two GDH genes products in leaves and stems of Nicotiana plumbaginifolia and Arabidopsis thaliana. Fontaine JX, et al. Plant Cell Physiol, 2006 Mar. PMID 16418233
  5. NAD(H)-dependent glutamate dehydrogenase is essential for the survival of Arabidopsis thaliana during dark-induced carbon starvation. Miyashita Y, et al. J Exp Bot, 2008. PMID 18296429

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
    Title: High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
  2. these data illustrate the essential role of EIN3-regulated GDH activity in metabolic adjustment during anoxia-reoxygenation.
    Title: Ethylene-Regulated Glutamate Dehydrogenase Fine-Tunes Metabolism during Anoxia-Reoxygenation.
  3. Protein phosphorylation by serine/threonine protein kinases is the essential step required for signal transduction into nucleus resulting in the induction of glutamate dehydrogenase 2 expression.
    Title: Induction of Arabidopsis gdh2 gene expression during changes in redox state of the mitochondrial respiratory chain.
  4. role in amino acid breakdown under C-deficient conditions
    Title: NAD(H)-dependent glutamate dehydrogenase is essential for the survival of Arabidopsis thaliana during dark-induced carbon starvation.
  5. In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate dehydrogenase are targeted to the mitochondria of the companion cells.
    Title: Control of the synthesis and subcellular targeting of the two GDH genes products in leaves and stems of Nicotiana plumbaginifolia and Arabidopsis thaliana.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001125711.2
NM_001125712.2
NM_120826.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables cobalt ion binding HDA PubMed 
enables copper ion binding HDA PubMed 
enables glutamate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
glutamate dehydrogenase 2
NP_001119183.1
  • glutamate dehydrogenase 2 (GDH2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), Glutamate dehydrogenase (InterPro:IPR014362), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 1 (TAIR:AT5G18170.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_001119184.1
  • glutamate dehydrogenase 2 (GDH2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 3 (TAIR:AT3G03910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_196361.1
  • glutamate dehydrogenase 2 (GDH2); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), Glutamate dehydrogenase (InterPro:IPR014362), NAD(P)-binding domain (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: glutamate dehydrogenase 1 (TAIR:AT5G18170.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    2355759..2358241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120826.3 → NP_196361.1  glutamate dehydrogenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38946
    UniProtKB/TrEMBL
    A0A178UEW8, A0A5S9Y275, A0A7G2F914
    Conserved Domains (1) summary
    PLN02477
    Location:1 → 410
    PLN02477; glutamate dehydrogenase

  2. NM_001125711.2 → NP_001119183.1  glutamate dehydrogenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119183.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38946
    UniProtKB/TrEMBL
    A0A178UEW8, A0A5S9Y275, A0A7G2F914
    Conserved Domains (1) summary
    PLN02477
    Location:1 → 410
    PLN02477; glutamate dehydrogenase

  3. NM_001125712.2 → NP_001119184.1  glutamate dehydrogenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0Z209, F4K6P9
    Conserved Domains (3) summary
    PLN02477
    Location:1 → 296
    PLN02477; glutamate dehydrogenase
    pfam02812
    Location:31 → 159
    ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain
    cl21454
    Location:176 → 296
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38946.1

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