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SNX2b sorting nexin 2B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830603, updated on 18-Sep-2024

Summary

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Official Symbol
SNX2b
Official Full Name
sorting nexin 2B
Primary source
TAIR:AT5G07120
Locus tag
AT5G07120
See related
Araport:AT5G07120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
sorting nexin 2B; T28J14.60; T28J14_60
Summary
Encodes sorting nexin SNX2b. SNX2b is peripherally associated with membranes. Involved in vesicular trafficking from endosomes to the vacuole.
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Genomic context

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See SNX2b in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (2206894..2209556, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 26 Neighboring gene prenylated RAB acceptor 1.B6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene laccase 13 Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Arabidopsis sorting nexin AtSNX2b inhibits endocytic trafficking to the vacuole. Phan NQ, et al. Mol Plant, 2008 Nov. PMID 19825596
  2. Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis. Hirano T, et al. Plant Signal Behav, 2016. PMID 26515455, Free PMC Article
  3. Analyses of sorting nexins reveal distinct retromer-subcomplex functions in development and protein sorting in Arabidopsis thaliana. Pourcher M, et al. Plant Cell, 2010 Dec. PMID 21156856, Free PMC Article
  4. Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Oliviusson P, et al. Plant Cell, 2006 May. PMID 16582012, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. overexpression of FAB1A-GFP reassembles SNX2b-mRFP on the endosomal membrane despite the absence of SNX1.
    Title: Overexpression of FAB1A-GFP recruits SNX2b on the endosome membrane in snx1-1 mutant in Arabidopsis.
  2. AtSNX2b is involved in vesicular trafficking from endosomes to the vacuole. [AtSNX2b]
    Title: Overexpression of Arabidopsis sorting nexin AtSNX2b inhibits endocytic trafficking to the vacuole.
Submit: New GeneRIF Correction

General gene information

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Markers

NM_001342920.1
NM_001342921.1
NM_120794.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within developmental process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seedling development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
part_of retromer complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sorting nexin 2B
NP_196329.2
  • sorting nexin 2B (SNX2b); FUNCTIONS IN: phospholipid binding; INVOLVED IN: vesicle-mediated transport, intracellular signaling pathway; LOCATED IN: membrane; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Vps5 C-terminal (InterPro:IPR015404), Phox-like (InterPro:IPR001683); BEST Arabidopsis thaliana protein match is: sorting nexin 2A (TAIR:AT5G58440.1); Has 2399 Blast hits to 2386 proteins in 279 species: Archae - 13; Bacteria - 100; Metazoa - 1366; Fungi - 555; Plants - 146; Viruses - 0; Other Eukaryotes - 219 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    2206894..2209556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120794.4 → NP_196329.2  sorting nexin 2B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196329.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFS6, Q0WLC3, Q570X1, Q9LYQ3
    UniProtKB/TrEMBL
    A0A5S9Y2E5, A0A654FZ53
    Conserved Domains (2) summary
    cd06865
    Location:143 → 263
    PX_SNX_like; The phosphoinositide binding Phox Homology domain of SNX-like proteins
    cd07596
    Location:335 → 563
    BAR_SNX; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins

  2. NM_001342920.1 → NP_001331853.1  sorting nexin 2B [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFS6, Q0WLC3, Q570X1, Q9LYQ3
    UniProtKB/TrEMBL
    A0A5S9Y2E5, A0A654FZ53
    Conserved Domains (2) summary
    cd06865
    Location:143 → 263
    PX_SNX_like; The phosphoinositide binding Phox Homology domain of SNX-like proteins
    cd07596
    Location:335 → 563
    BAR_SNX; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins

  3. NM_001342921.1 → NP_001331854.1  sorting nexin 2B [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BF56, A0A5S9Y2E5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9DFS6.1

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