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FAD-linked oxidases family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830546, updated on 18-Sep-2024

Summary

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Official Full Name
FAD-linked oxidases family protein
Primary source
TAIR:AT5G06580
Locus tag
AT5G06580
See related
Araport:AT5G06580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F15M7.11; F15M7_11
Summary
Encodes a protein with glycolate dehydrogenase activity, which was shown to complement various subunits of the E. coli glycolate oxidase complex. It has not been ruled out that the enzyme might be involved in other catalytic activities in vivo.
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Genomic context

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Location:
chromosome: 5
Exon count:
18
Sequence:
Chromosome: 5; NC_003076.8 (2011245..2016583, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myosin-binding protein (Protein of unknown function, DUF593) Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene ubiquitin-specific protease 12 Neighboring gene lipase (DUF620)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. D-Lactate dehydrogenase as a marker gene allows positive selection of transgenic plants. Wienstroer J, et al. FEBS Lett, 2012 Jan 2. PMID 22155004
  2. Mitochondrial glycolate oxidation contributes to photorespiration in higher plants. Niessen M, et al. J Exp Bot, 2007. PMID 17595195
  3. A glycolate dehydrogenase in the mitochondria of Arabidopsis thaliana. Bari R, et al. J Exp Bot, 2004 Mar. PMID 14966218
  4. d-Lactate Dehydrogenase Links Methylglyoxal Degradation and Electron Transport through Cytochrome c. Welchen E, et al. Plant Physiol, 2016 Oct. PMID 27506242, Free PMC Article
  5. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. Engqvist M, et al. J Biol Chem, 2009 Sep 11. PMID 19586914, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of d-Lactate dehydrogenase (d-LDH) and cytochrome c (CYTc) increased tolerance to d-lactate and methylglyoxal (MGO.
    Title: d-Lactate Dehydrogenase Links Methylglyoxal Degradation and Electron Transport through Cytochrome c.
  2. AtGDH contributes to glycolate metabolism in Arabidopsis, indicating conservation of the chlorophyte pathway in higher plants. [AtGDH] [GDH]
    Title: Mitochondrial glycolate oxidation contributes to photorespiration in higher plants.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_120741.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables D-lactate dehydrogenase (cytochrome) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycolate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within methylglyoxal catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylglyoxal catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
FAD-linked oxidases family protein
NP_568170.1
  • FAD-linked oxidases family protein; FUNCTIONS IN: glycolate oxidase activity, glycolate dehydrogenase activity, D-lactate dehydrogenase (cytochrome) activity, ATP binding; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-linked oxidase, FAD-binding, subdomain 2 (InterPro:IPR016168), FAD-binding, type 2 (InterPro:IPR016166), FAD-linked oxidase, C-terminal (InterPro:IPR004113), FAD-linked oxidase-like, C-terminal (InterPro:IPR016164), FAD linked oxidase, N-terminal (InterPro:IPR006094), FAD-binding, type 2, subdomain 1 (InterPro:IPR016167); BEST Arabidopsis thaliana protein match is: FAD-linked oxidases family protein (TAIR:AT4G36400.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    2011245..2016583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120741.3 → NP_568170.1  FAD-linked oxidases family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94AX4, Q9FG12
    UniProtKB/TrEMBL
    A0A178UIT0, A0A5S9Y1Y8, A0A654FYU6
    Conserved Domains (1) summary
    PLN02805
    Location:9 → 567
    PLN02805; D-lactate dehydrogenase [cytochrome]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94AX4.1

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