AtPOT1b Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AtPOT1b
Official Full Name: Nucleic acid-binding, OB-fold-like protein
Primary source: TAIR:AT5G06310
Locus tag: AT5G06310
See related: Araport:AT5G06310
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MHF15.17; MHF15_17; protection of telomeres 1b
Summary: Encodes AtPOT1b. Note on nomenclature: different names have been given to Arabidopsis POT-like genes (Kuchar and Fajkus, 2004; Shakirov et al, 2005; Tani and Murata, 2005). According to a unifying nomenclature (Surovtseva et al, 2007), At2g05210 (previously named AtPOT1) is designated AtPOT1a, while At5g06310 (previously named AtPOT2) is designated AtPOT1b.
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Genomic context

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See AtPOT1b in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 10

Sequence:: Chromosome: 5; NC_003076.8 (1928343..1930951)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-strand telomeric DNA binding activity present in A. thaliana nuclear extracts is not dependent on POT1a or POT1b proteins.
Title: POT1-independent single-strand telomeric DNA binding activities in Brassicaceae.
The domains responsible for that interaction AtTRB1 and AtPOT1b were identified.
Title: Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
AtPot1 (protection of telomeres 1) and AtPot2 (protection of telomeres 2)are ubiquitously expressed at low levels in Arabidopsis. AtPot2 is involved in chromosome end protection. [Atpot2]
Title: The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120714.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded telomeric DNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Nucleic acid-binding, OB-fold-like protein

NP_196249.2

protection of telomeres 1b (AtPOT1b); FUNCTIONS IN: DNA binding; INVOLVED IN: telomere maintenance; LOCATED IN: nuclear chromosome, telomeric region; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Telomere end binding protein (InterPro:IPR011564); BEST Arabidopsis thaliana protein match is: Nucleic acid-binding, OB-fold-like protein (TAIR:AT2G05210.3); Has 198 Blast hits to 197 proteins in 63 species: Archae - 0; Bacteria - 0; Metazoa - 81; Fungi - 0; Plants - 83; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1928343..1930951

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120714.4 → NP_196249.2 Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196249.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4W6W7, Q6NKX5, Q9FNH7

UniProtKB/TrEMBL

A0A178UKU3, A0A5S9Y2Q5, A0A654FZB3

Conserved Domains (2) summary

cd04497
Location:9 → 143

hPOT1_OB1_like; A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the ...

cl09930
Location:158 → 196

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.