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SYN1 Rad21/Rec8-like family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830432, updated on 18-Sep-2024

Summary

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Official Symbol
SYN1
Official Full Name
Rad21/Rec8-like family protein
Primary source
TAIR:AT5G05490
Locus tag
AT5G05490
See related
Araport:AT5G05490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtREC8; ATREC8; BP2; DETERMINATE; DIF1; INFERTILE 1; MOP10.3; MOP10_3; REC8; SYNAPTIC 1
Summary
Encodes a RAD21-like gene essential for meiosis. Encodes a 627 a.a. protein that is slightly longer in the N-terminus than SYN1 BP5.
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Genomic context

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See SYN1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
21
Sequence:
Chromosome: 5; NC_003076.8 (1624206..1629269)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene eukaryotic translation initiation factor 2 alpha subunit Neighboring gene Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene Mad3/BUB1 homology region 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interacting Genomic Landscapes of REC8-Cohesin, Chromatin, and Meiotic Recombination in Arabidopsis. Lambing C, et al. Plant Cell, 2020 Apr. PMID 32024691, Free PMC Article
  2. Isolation and characterization of SYN1, a RAD21-like gene essential for meiosis in Arabidopsis. Bai X, et al. Plant Cell, 1999 Mar. PMID 10072401, Free PMC Article
  3. ASK1, a SKP1 homolog, is required for nuclear reorganization, presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis. Zhao D, et al. Plant Mol Biol, 2006 Sep. PMID 16897472
  4. SWI1 is required for meiotic chromosome remodeling events. Boateng KA, et al. Mol Plant, 2008 Jul. PMID 19825567
  5. AtREC8 and AtSCC3 are essential to the monopolar orientation of the kinetochores during meiosis. Chelysheva L, et al. J Cell Sci, 2005 Oct 15. PMID 16176934

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interacting Genomic Landscapes of REC8-Cohesin, Chromatin, and Meiotic Recombination in Arabidopsis.
    Title: Interacting Genomic Landscapes of REC8-Cohesin, Chromatin, and Meiotic Recombination in Arabidopsis.
  2. ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization.
    Title: ASK1, a SKP1 homolog, is required for nuclear reorganization, presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis.
  3. REC8 and SCC3 are necessary not only to maintain centromere cohesion at anaphase I, but also for the monopolar orientation of the kinetochores during the first meiotic division [AtREC8]
    Title: AtREC8 and AtSCC3 are essential to the monopolar orientation of the kinetochores during meiosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_120631.2
NM_180442.2

Gene Ontology Provided by TAIR

Process Evidence Code Pubs
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spindle attachment to meiosis I kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cohesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Rad21/Rec8-like family protein
NP_196168.1
  • SYNAPTIC 1 (SYN1); CONTAINS InterPro DOMAIN/s: Rad21/Rec8 like protein, C-terminal (InterPro:IPR006909), Rad21/Rec8 like protein, N-terminal (InterPro:IPR006910); BEST Arabidopsis thaliana protein match is: sister chromatid cohesion 1 protein 4 (TAIR:AT5G16270.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_850773.1
  • SYNAPTIC 1 (SYN1); CONTAINS InterPro DOMAIN/s: Rad21/Rec8 like protein, C-terminal (InterPro:IPR006909), Rad21/Rec8 like protein, N-terminal (InterPro:IPR006910); BEST Arabidopsis thaliana protein match is: sister chromatid cohesion 1 protein 4 (TAIR:AT5G16270.1); Has 648 Blast hits to 629 proteins in 171 species: Archae - 0; Bacteria - 0; Metazoa - 226; Fungi - 209; Plants - 165; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1624206..1629269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180442.2 → NP_850773.1  Rad21/Rec8-like family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850773.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E9L1, Q9S7T7, Q9SQI1
    UniProtKB/TrEMBL
    A0A178UHG0
    Conserved Domains (2) summary
    pfam04824
    Location:573 → 627
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:16 → 117
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

  2. NM_120631.2 → NP_196168.1  Rad21/Rec8-like family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196168.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UHG0, A0A5S9Y1W9, A0A654FZ23
    Conserved Domains (2) summary
    pfam04824
    Location:563 → 617
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1 → 107
    Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9S7T7.2

Gene LinkOut

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