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EIF2 ALPHA eukaryotic translation initiation factor 2 alpha subunit [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830430, updated on 18-Sep-2024

Summary

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Official Symbol
EIF2 ALPHA
Official Full Name
eukaryotic translation initiation factor 2 alpha subunit
Primary source
TAIR:AT5G05470
Locus tag
AT5G05470
See related
Araport:AT5G05470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATEIF2-A2; EIF2-A2; eukaryotic translation initiation factor 2 alpha subunit
Summary
Encodes an eIF2alpha homolog that can be phosphorylated by GCN2 in vitro.
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Genomic context

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See EIF2 ALPHA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (1620458..1622340)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase family 85 Neighboring gene ncRNA Neighboring gene Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein Neighboring gene Rad21/Rec8-like family protein Neighboring gene Pollen Ole e 1 allergen and extensin family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the alpha-subunit of plant eukaryotic initiation factor 2 prevents its association with polysomes but does not considerably suppress protein synthesis. Zhigailov AV, et al. Plant Sci, 2022 Apr. PMID 35193739
  2. GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis. Zhang Y, et al. J Exp Bot, 2008. PMID 18603615, Free PMC Article
  3. The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates. Li MW, et al. Plant Biol (Stuttg), 2013 Jan. PMID 22672016
  4. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
  5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of the alpha-subunit of plant eukaryotic initiation factor 2 prevents its association with polysomes but does not considerably suppress protein synthesis.
    Title: Phosphorylation of the alpha-subunit of plant eukaryotic initiation factor 2 prevents its association with polysomes but does not considerably suppress protein synthesis.
  2. The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
    Title: The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates.
  3. Analysis of wild-type and GT8359 (null mutant for AtGCN2) plants infected with Turnip yellow mosaic virus or Turnip crinkle virus showed that AteIF2alpha was not phosphorylated.
    Title: GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_120629.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
part_of eukaryotic translation initiation factor 2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 alpha subunit
NP_196166.1
  • eukaryotic translation initiation factor 2 alpha subunit (EIF2 ALPHA); FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; LOCATED IN: eukaryotic translation initiation factor 2 complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: Eukaryotic translation initiation factor 2 subunit 1 (TAIR:AT2G40290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1620458..1622340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120629.3 → NP_196166.1  eukaryotic translation initiation factor 2 alpha subunit [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9C5N6, Q9FE78
    UniProtKB/TrEMBL
    A0A178UAX7, A0A5S9Y2G1, A0A654FYH9
    Conserved Domains (1) summary
    PTZ00248
    Location:5 → 315
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FE78.1

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