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SUVH1 SU(VAR)3-9 homolog 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830376, updated on 18-Sep-2024

Summary

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Official Symbol
SUVH1
Official Full Name
SU(VAR)3-9 homolog 1
Primary source
TAIR:AT5G04940
Locus tag
AT5G04940
See related
Araport:AT5G04940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MUG13.20; MUG13_20; SU(VAR)3-9 homolog 1
Summary
Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain.
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Genomic context

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See SUVH1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_003076.8 (1454131..1457141, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pol-like polyprotein/retrotransposon Neighboring gene uncharacterized protein Neighboring gene nicotianamine synthase 1 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. Li S, et al. Nucleic Acids Res, 2016 Jan 29. PMID 26400170, Free PMC Article
  2. A DNA methylation reader complex that enhances gene transcription. Harris CJ, et al. Science, 2018 Dec 7. PMID 30523112, Free PMC Article
  3. A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes. Zhao QQ, et al. J Integr Plant Biol, 2019 Feb. PMID 30589221
  4. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes. Baumbusch LO, et al. Nucleic Acids Res, 2001 Nov 1. PMID 11691919, Free PMC Article
  5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUVH1 promotes the expression of genes targeted by DNA methylation.
    Title: SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_120576.1
NM_180436.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
SU(VAR)3-9 homolog 1
NP_196113.1
  • SU(VAR)3-9 homolog 1 (SUVH1); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), SRA-YDG (InterPro:IPR003105), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Post-SET domain (InterPro:IPR003616), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 3 (TAIR:AT1G73100.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_850767.1
  • SU(VAR)3-9 homolog 1 (SUVH1); CONTAINS InterPro DOMAIN/s: SRA-YDG (InterPro:IPR003105), SET domain (InterPro:IPR001214), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Post-SET domain (InterPro:IPR003616), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 3 (TAIR:AT1G73100.1); Has 4151 Blast hits to 3953 proteins in 385 species: Archae - 0; Bacteria - 260; Metazoa - 2116; Fungi - 479; Plants - 984; Viruses - 5; Other Eukaryotes - 307 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1454131..1457141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180436.2 → NP_850767.1  SU(VAR)3-9 homolog 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850767.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FF80
    UniProtKB/TrEMBL
    A0A178UBV2, A0A5S9Y224, C0SVN4
    Conserved Domains (3) summary
    smart00466
    Location:207 → 361
    SRA; SET and RING finger associated domain
    smart00317
    Location:495 → 639
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:389 → 487
    Pre-SET; Pre-SET motif

  2. NM_120576.1 → NP_196113.1  SU(VAR)3-9 homolog 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196113.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FF80
    UniProtKB/TrEMBL
    A0A178UBV2, A0A5S9Y224, C0SVN4
    Conserved Domains (3) summary
    smart00466
    Location:207 → 361
    SRA; SET and RING finger associated domain
    smart00317
    Location:495 → 639
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:389 → 487
    Pre-SET; Pre-SET motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FF80.1

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