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HCC2 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830129, updated on 18-Sep-2024

Summary

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Official Symbol
HCC2
Official Full Name
Thioredoxin superfamily protein
Primary source
TAIR:AT4G39740
Locus tag
AT4G39740
See related
Araport:AT4G39740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
homologue of copper chaperone SCO1 2; T19P19.130; T19P19_130
Summary
Encodes HCC2, one of the two Arabidopsis genes (HCC1 and HCC2) resulting from a duplication with homology to the SCO proteins involved in copper insertion during cytochrome c oxidase (COX) assembly in other organisms. HCC2, which lacks the cysteines and histidine putatively involved in copper binding, functions in copper sensing and redox homeostasis.
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Genomic context

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See HCC2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
7
Sequence:
Chromosome: 4; NC_003075.7 (18435293..18437258, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene VQ motif-containing protein Neighboring gene Lipase/lipooxygenase, PLAT/LH2 family protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene F-box family protein-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plants contain two SCO proteins that are differentially involved in cytochrome c oxidase function and copper and redox homeostasis. Attallah CV, et al. J Exp Bot, 2011 Aug. PMID 21543521
  2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_120135.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Thioredoxin superfamily protein
NP_568068.1
  • Thioredoxin superfamily protein; CONTAINS InterPro DOMAIN/s: Copper chaperone SCO1/SenC (InterPro:IPR003782), Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: electron transport SCO1/SenC family protein (TAIR:AT3G08950.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    18435293..18437258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120135.5 → NP_568068.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65661, Q8LAL0
    UniProtKB/TrEMBL
    A0A178V000, A0A5S9Y0U0
    Conserved Domains (1) summary
    cd02968
    Location:115 → 255
    SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LAL0.1

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