LAZ1 organic solute transporter ostalpha protein (DUF300) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LAZ1
Official Full Name: organic solute transporter ostalpha protein (DUF300)
Primary source: TAIR:AT4G38360
Locus tag: AT4G38360
See related: Araport:AT4G38360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F22I13.130; F22I13_130; LAZARUS 1
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Genomic context

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See LAZ1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (17967050..17969958)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the absence of two DUF300 domain-containing tonoplast proteins, LAZARUS1 (LAZ1) and LAZ1 HOMOLOG1 (LAZ1H1), causes vacuole morphology defects, growth inhibition, and constitutive activation of BR signaling
Title: Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling Regulation.
Lazarus1 (AT4G38360)contributes to programmed cell death associated with acd11 and the hypersensitive response.
Title: Lazarus1, a DUF300 protein, contributes to programmed cell death associated with Arabidopsis acd11 and the hypersensitive response.

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General gene information

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Homology

Orthologs from OrthoDB

NM_119998.2

Supported by ESTs:

NM_202977.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of brassinosteroid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vacuole organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport to the plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: organic solute transporter ostalpha protein (DUF300)

NP_568039.1

Protein of unknown function (DUF300); INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF300 (InterPro:IPR005178); BEST Arabidopsis thaliana protein match is: Protein of unknown function (DUF300) (TAIR:AT1G77220.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974706.1

Protein of unknown function (DUF300); INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF300 (InterPro:IPR005178); BEST Arabidopsis thaliana protein match is: Protein of unknown function (DUF300) (TAIR:AT1G77220.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17967050..17969958

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119998.2 → NP_568039.1 organic solute transporter ostalpha protein (DUF300) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568039.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JTN2

Conserved Domains (1) summary

pfam03619
Location:22 → 284

Solute_trans_a; Organic solute transporter Ostalpha
NM_202977.1 → NP_974706.1 organic solute transporter ostalpha protein (DUF300) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974706.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JTN2, Q94AJ4, Q9SVE9

UniProtKB/TrEMBL

A0A178UWL9, A0A5S9Y0D4, A0A7G2F3S2

Conserved Domains (1) summary

pfam03619
Location:22 → 300

Solute_trans_a; Organic solute transporter Ostalpha