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GRF2 growth-regulating factor 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829930, updated on 18-Sep-2024

Summary

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Official Symbol
GRF2
Official Full Name
growth-regulating factor 2
Primary source
TAIR:AT4G37740
Locus tag
AT4G37740
See related
Araport:AT4G37740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtGRF2; growth-regulating factor 2; T28I19.20; T28I19_20
Summary
Growth regulating factor encoding transcription activator. One of the nine members of a GRF gene family, containing nuclear targeting domain. Mutants result in smaller leaves indicating the role of the gene in leaf development. Expressed in root, shoot and flower
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Genomic context

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See GRF2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Sequence:
Chromosome: 4; NC_003075.7 (17725337..17727909, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene basic leucine-zipper 7 Neighboring gene ncRNA Neighboring gene Integrase-type DNA-binding superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional specialization of the plant miR396 regulatory network through distinct microRNA-target interactions. Debernardi JM, et al. PLoS Genet, 2012 Jan. PMID 22242012, Free PMC Article
  2. MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots. Rodriguez RE, et al. Plant Cell, 2015 Dec. PMID 26645252, Free PMC Article
  3. Control of cell proliferation in Arabidopsis thaliana by microRNA miR396. Rodriguez RE, et al. Development, 2010 Jan. PMID 20023165, Free PMC Article
  4. A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis. Kim JH, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15326298, Free PMC Article
  5. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Kim JH, et al. Plant J, 2003 Oct. PMID 12974814

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_119936.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leaf development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
growth-regulating factor 2
NP_195488.2
  • growth-regulating factor 2 (GRF2); CONTAINS InterPro DOMAIN/s: Glutamine-Leucine-Glutamine, QLQ (InterPro:IPR014978), WRC (InterPro:IPR014977); BEST Arabidopsis thaliana protein match is: growth-regulating factor 1 (TAIR:AT2G22840.1); Has 745 Blast hits to 714 proteins in 55 species: Archae - 0; Bacteria - 0; Metazoa - 33; Fungi - 24; Plants - 532; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    17725337..17727909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119936.5 → NP_195488.2  growth-regulating factor 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195488.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L8A8, Q9T063
    UniProtKB/TrEMBL
    A0A178UXW8, A0A5S9Y0F1
    Conserved Domains (2) summary
    pfam08879
    Location:228 → 269
    WRC
    pfam08880
    Location:164 → 198
    QLQ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L8A8.1

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