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MLH3 MUTL protein homolog 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829704, updated on 18-Sep-2024

Summary

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Official Symbol
MLH3
Official Full Name
MUTL protein homolog 3
Primary source
TAIR:AT4G35520
Locus tag
AT4G35520
See related
Araport:AT4G35520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMLH3; F8D20.30; F8D20_30; MUTL protein homolog 3
Summary
DNA mismatch repair protein similar to MutL. Required for normal levels of meiotic crossovers
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Genomic context

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See MLH3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
24
Sequence:
Chromosome: 4; NC_003075.7 (16865304..16871527)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene PHD finger-like protein Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositolglycan-like protein Neighboring gene ncRNA Neighboring gene POLLEN-EXPRESSED TRANSCRIPTION FACTOR 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis. Jackson N, et al. EMBO J, 2006 Mar 22. PMID 16467846, Free PMC Article
  2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

General gene information

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NM_001342354.1
NM_001342358.1
NM_001342359.1
NM_001342360.1
NM_119717.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mismatch repair complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MUTL protein homolog 3
NP_001320143.1
  • MUTL protein homolog 3 (MLH3); FUNCTIONS IN: mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, reciprocal meiotic recombination; LOCATED IN: chromosome; EXPRESSED IN: inflorescence; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein, N-terminal (InterPro:IPR014763), MutL, C-terminal, dimerisation (InterPro:IPR014790), DNA mismatch repair protein (InterPro:IPR002099), DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594); BEST Arabidopsis thaliana protein match is: DNA mismatch repair protein, putative (TAIR:AT4G02460.1); Has 8909 Blast hits to 6784 proteins in 2360 species: Archae - 138; Bacteria - 6148; Metazoa - 581; Fungi - 681; Plants - 158; Viruses - 0; Other Eukaryotes - 1203 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16865304..16871527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001342355.1 → NP_001328252.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V761, A0A1P8B445

  2. NM_001342356.1 → NP_001328253.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V7B3, A0A1P8B434

  3. NM_001342357.1 → NP_001328256.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B439, A0A654FVR9

  4. NM_001342354.1 → NP_001320143.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JN26, O81785
    UniProtKB/TrEMBL
    A0A654FVR9

  5. NM_001342358.1 → NP_001328251.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B465, A0A654FVR9

  6. NM_001342359.1 → NP_001328254.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B429, A0A654FVR9

  7. NM_119717.7 → NP_195277.6  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B406

  8. NM_001342360.1 → NP_001328255.1  MUTL protein homolog 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B459
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4JN26.2

Gene LinkOut

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