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XLG2 extra-large GTP-binding protein 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829589, updated on 18-Sep-2024

Summary

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Official Symbol
XLG2
Official Full Name
extra-large GTP-binding protein 2
Primary source
TAIR:AT4G34390
Locus tag
AT4G34390
See related
Araport:AT4G34390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
extra-large GTP-binding protein 2; F10M10.160; F10M10_160
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Genomic context

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See XLG2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Sequence:
Chromosome: 4; NC_003075.7 (16441086..16445017)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions. Maruta N, et al. Plant Physiol, 2021 Jun 11. PMID 33729516, Free PMC Article
  2. XLG2 and CORI3 function additively to regulate plant defense against the necrotrophic pathogen Sclerotinia sclerotiorum. Tiwari R, et al. Plant J, 2024 Jan. PMID 37910396
  3. EXTRA LARGE G-PROTEIN2 mediates cell death and hyperimmunity in the chitin elicitor receptor kinase 1-4 mutant. Petutschnig E, et al. Plant Physiol, 2022 Aug 1. PMID 35522044, Free PMC Article
  4. Arabidopsis extra large G-protein 2 (XLG2) interacts with the Gbeta subunit of heterotrimeric G protein and functions in disease resistance. Zhu H, et al. Mol Plant, 2009 May. PMID 19825634, Free PMC Article
  5. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity. Wang Y, et al. J Integr Plant Biol, 2023 Mar. PMID 36250681

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. XLG2 and CORI3 function additively to regulate plant defense against the necrotrophic pathogen Sclerotinia sclerotiorum.
    Title: XLG2 and CORI3 function additively to regulate plant defense against the necrotrophic pathogen Sclerotinia sclerotiorum.
  2. Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
    Title: Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity.
  3. GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions.
    Title: GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions.
  4. XLG2 interaction with PUB4 and PUB2
    Title: EXTRA-LARGE G PROTEINs Interact with E3 Ligases PUB4 and PUB2 and Function in Cytokinin and Developmental Processes.
  5. XLGs can bind Gbetagamma dimers.
    Title: Extra-Large G Proteins Expand the Repertoire of Subunits in Arabidopsis Heterotrimeric G Protein Signaling.
  6. a Ca(2+)-dependent G protein, XLG2, promotes RTV1 DNA binding activity for a subset of floral integrator genes and contributes to floral transition.
    Title: Ca2+-dependent GTPase, extra-large G protein 2 (XLG2), promotes activation of DNA-binding protein related to vernalization 1 (RTV1), leading to activation of floral integrator genes and early flowering in Arabidopsis.
  7. study describes initial functional characterization of XLG1, XLG2 & XZLG3 genes & reveals a role for XLG proteins in the regulation of root growth and seed germination by sugars and phytohormones
    Title: Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001342282.1
NM_119604.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of plant-type hypersensitive response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of root morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to fructose IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to glucose IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to mannitol IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to sucrose IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
extra-large GTP-binding protein 2
NP_195165.2
  • extra-large GTP-binding protein 2 (XLG2); FUNCTIONS IN: guanyl nucleotide binding, signal transducer activity; INVOLVED IN: in 7 processes; LOCATED IN: nucleus; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Guanine nucleotide binding protein (G-protein), alpha subunit (InterPro:IPR001019), G protein alpha subunit, helical insertion (InterPro:IPR011025); BEST Arabidopsis thaliana protein match is: extra-large G-protein 1 (TAIR:AT2G23460.1); Has 3202 Blast hits to 3201 proteins in 381 species: Archae - 0; Bacteria - 2; Metazoa - 2082; Fungi - 561; Plants - 350; Viruses - 0; Other Eukaryotes - 207 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16441086..16445017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119604.4 → NP_195165.2  extra-large GTP-binding protein 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195165.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C6KIE6, Q9SZ04
    UniProtKB/TrEMBL
    A0A178V358, A0A5S9XZE8
    Conserved Domains (1) summary
    cd00066
    Location:464 → 840
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  2. NM_001342282.1 → NP_001328987.1  extra-large GTP-binding protein 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B6B8, A0A654FVH4, A0A7G2F4Q1
    Conserved Domains (1) summary
    cd00066
    Location:464 → 801
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C6KIE6.1

Gene LinkOut

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