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HB-8 homeobox-leucine zipper protein ATHB-8 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829424, updated on 18-Sep-2024

Summary

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Official Symbol
HB-8
Official Full Name
homeobox-leucine zipper protein ATHB-8
Primary source
TAIR:AT4G32880
Locus tag
AT4G32880
See related
Araport:AT4G32880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATHB-8; ATHB8; homeobox gene 8; T16I18.90; T16I18_90
Summary
member of homeodomain-leucine zipper family, acting as a differentiation-promoting transcription factor of the vascular meristems.
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Genomic context

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See HB-8 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
18
Sequence:
Chromosome: 4; NC_003075.7 (15863339..15868650, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Avr9/Cf-9 rapidly elicited protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene GATA transcription factor 9 Neighboring gene Peptidyl-tRNA hydrolase II (PTH2) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The expression of the Athb-8 homeobox gene is restricted to provascular cells in Arabidopsis thaliana. Baima S, et al. Development, 1995 Dec. PMID 8575317
  2. Simultaneous activation of SHR and ATHB8 expression defines switch to preprocambial cell state in Arabidopsis leaf development. Gardiner J, et al. Dev Dyn, 2011 Jan. PMID 21128301
  3. Auxin signal transduction in Arabidopsis vein formation. Donner TJ, et al. Plant Signal Behav, 2010 Jan. PMID 20592815, Free PMC Article
  4. Auxin signaling in Arabidopsis leaf vascular development. Mattsson J, et al. Plant Physiol, 2003 Mar. PMID 12644682, Free PMC Article
  5. The arabidopsis ATHB-8 HD-zip protein acts as a differentiation-promoting transcription factor of the vascular meristems. Baima S, et al. Plant Physiol, 2001 Jun. PMID 11402194, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Congruence between SHR and ATHB8 expression domains persists under conditions of manipulated vein patterning, suggesting that inception of expression of SHR and ATHB8 identifies transition to a preprocambial cell state that presages vein formation.
    Title: Simultaneous activation of SHR and ATHB8 expression defines switch to preprocambial cell state in Arabidopsis leaf development.
  2. Data show that the expression of 3 DOF genes DOF2.1 (At2g28510), DOF4.6 (At4g24060) and DOF5.3 (At5g60200) is activated at early vascular development stages overlapping onset of ATHB8 expression.
    Title: Expression of DOF genes identifies early stages of vascular development in Arabidopsis leaves.
  3. Here we discuss putative mechanisms by which wide domains of MP expression could activate ATHB8 transcription in single cell files.
    Title: Auxin signal transduction in Arabidopsis vein formation.
  4. Class III HD-Zip AND KANADI genes required for root development [ATHB8]
    Title: Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_119441.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within meristem initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within primary shoot apical meristem specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within procambium histogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to auxin IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within xylem development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
homeobox-leucine zipper protein ATHB-8
NP_195014.1
  • homeobox gene 8 (HB-8); CONTAINS InterPro DOMAIN/s: Basic-leucine zipper (bZIP) transcription factor (InterPro:IPR004827), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), MEKHLA (InterPro:IPR013978), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein (TAIR:AT1G52150.1); Has 3304 Blast hits to 3224 proteins in 267 species: Archae - 0; Bacteria - 6; Metazoa - 860; Fungi - 101; Plants - 2302; Viruses - 0; Other Eukaryotes - 35 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15863339..15868650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119441.5 → NP_195014.1  homeobox-leucine zipper protein ATHB-8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195014.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39123
    UniProtKB/TrEMBL
    A0A178UUJ8, A0A5S9XYI2
    Conserved Domains (4) summary
    cd08875
    Location:154 → 369
    START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
    cd14686
    Location:67 → 106
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    pfam00046
    Location:15 → 73
    Homeobox; Homeobox domain
    pfam08670
    Location:692 → 832
    MEKHLA; MEKHLA domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39123.1

Gene LinkOut

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