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SHM3 serine hydroxymethyltransferase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829387, updated on 18-Sep-2024

Summary

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Official Symbol
SHM3
Official Full Name
serine hydroxymethyltransferase 3
Primary source
TAIR:AT4G32520
Locus tag
AT4G32520
See related
Araport:AT4G32520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtSHMT3; L23H3.3; serine hydroxymethyltransferase 3; SERINE HYDROXYMETHYLTRANSFERASE 3
Summary
Encodes a serine hydroxymethyltransferase SHMT3 located in the plastid.
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Genomic context

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See SHM3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Sequence:
Chromosome: 4; NC_003075.7 (15689436..15692989, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene K+ transporter 5 Neighboring gene HCO3- transporter family Neighboring gene ATPase, F0/V0 complex, subunit C protein Neighboring gene uncharacterized protein Neighboring gene Flavin-binding monooxygenase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. One-carbon metabolism in plants: characterization of a plastid serine hydroxymethyltransferase. Zhang Y, et al. Biochem J, 2010 Aug 15. PMID 20518745
  2. Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives. Nogués I, et al. Plant Physiol Biochem, 2022 Sep 15. PMID 35947902
  3. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
  4. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
  5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001125626.1
NM_119404.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glycine hydroxymethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plastid IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase 3
NP_001119098.1
  • serine hydroxymethyltransferase 3 (SHM3); FUNCTIONS IN: glycine hydroxymethyltransferase activity; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_567895.1
  • serine hydroxymethyltransferase 3 (SHM3); FUNCTIONS IN: glycine hydroxymethyltransferase activity; INVOLVED IN: glycine metabolic process, L-serine metabolic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: serine transhydroxymethyltransferase 1 (TAIR:AT4G37930.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15689436..15692989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119404.3 → NP_567895.1  serine hydroxymethyltransferase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567895.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JUC7, Q94JQ3, Q9SUU0
    UniProtKB/TrEMBL
    A0A178UTK1, A0A5S9XXY6
    Conserved Domains (1) summary
    PLN03226
    Location:70 → 528
    PLN03226; serine hydroxymethyltransferase; Provisional

  2. NM_001125626.1 → NP_001119098.1  serine hydroxymethyltransferase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119098.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JUC7, Q94JQ3, Q9SUU0
    UniProtKB/TrEMBL
    A0A178UTK1, A0A5S9XXY6
    Conserved Domains (1) summary
    PLN03226
    Location:70 → 528
    PLN03226; serine hydroxymethyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94JQ3.2

Gene LinkOut

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