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RSZ22 serine/arginine-rich 22 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829285, updated on 18-Sep-2024

Summary

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Official Symbol
RSZ22
Official Full Name
serine/arginine-rich 22
Primary source
TAIR:AT4G31580
Locus tag
AT4G31580
See related
Araport:AT4G31580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
At-RSZ22; AtRSZ22; F28M20.230; F28M20_230; RS-containing zinc finger protein 22; RS-CONTAINING ZINC FINGER PROTEIN 22; RSZP22; serine/arginine-rich 22; SRZ-22; SRZ22
Summary
Encodes a Serine/arginine-rich (SR) protein RSZp22. SR proteins are splicing regulators that share a modular structure consisting of one or two N-terminal RNA recognition motif domains and a C-terminal RS-rich domain. RSZp22 is located in the nucleolus. It is a nucleocytoplasmic shuttling protein and an interacting partner to the Arabidopsis U1-70K. Barta et al (2010) have proposed a nomenclature for Serine/Arginine-Rich Protein Splicing Factors (SR proteins): Plant Cell. 2010, 22:2926.
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Genomic context

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See RSZ22 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Sequence:
Chromosome: 4; NC_003075.7 (15306544..15309035)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene high chlorophyll fluorescence 153 Neighboring gene nucleoporin Neighboring gene Cellulose-synthase-like C5 Neighboring gene UDP-N-acetylglucosamine (UAA) transporter family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel family of plant splicing factors with a Zn knuckle motif: examination of RNA binding and splicing activities. Lopato S, et al. Plant Mol Biol, 1999 Mar. PMID 10350090
  2. Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors. Tillemans V, et al. Plant Cell, 2006 Nov. PMID 17114353, Free PMC Article
  3. Overexpression of an Arabidopsis heterogeneous nuclear ribonucleoprotein gene, AtRNP1, affects plant growth and reduces plant tolerance to drought and salt stresses. Wang Z, et al. Biochem Biophys Res Commun, 2016 Apr 1. PMID 26923071
  4. The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins. Golovkin M, et al. Plant Cell, 1998 Oct. PMID 9761791, Free PMC Article
  5. Dynamic nucleocytoplasmic shuttling of an Arabidopsis SR splicing factor: role of the RNA-binding domains. Rausin G, et al. Plant Physiol, 2010 May. PMID 20237019, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggested that the overexpression of AtRNP1 negatively affects plant growth and abiotic stress tolerance.
    Title: Overexpression of an Arabidopsis heterogeneous nuclear ribonucleoprotein gene, AtRNP1, affects plant growth and reduces plant tolerance to drought and salt stresses.
  2. Functional RNA recognition motif RNP1 and zinc-knuckle are dispensable for the exclusive protein nuclear localization and speckle-like distribution.
    Title: Dynamic nucleocytoplasmic shuttling of an Arabidopsis SR splicing factor: role of the RNA-binding domains.
  3. Data demonstrate that members of different SR protein sub-families, includins RSZ-21,-22, and -33, localise into distinct populations of nuclear speckles with no, partial or complete co-localisation.
    Title: Co-localisation studies of Arabidopsis SR splicing factors reveal different types of speckles in plant cell nuclei.
  4. The dynamic distribution of the Arabidopsis thaliana SR proteins RSZp22 and RSp31 in the nucleolus, are demonstrated.
    Title: Insights into nuclear organization in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001085005.1
NM_119307.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
serine/arginine-rich 22
NP_001078474.1
  • serine/arginine-rich 22 (SRZ-22); FUNCTIONS IN: protein binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: nuclear speck, nucleolus, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: RNA recognition motif and CCHC-type zinc finger domains containing protein (TAIR:AT2G24590.1); Has 12597 Blast hits to 10987 proteins in 687 species: Archae - 4; Bacteria - 845; Metazoa - 6508; Fungi - 1364; Plants - 2624; Viruses - 137; Other Eukaryotes - 1115 (source: NCBI BLink).
NP_194886.1
  • serine/arginine-rich 22 (SRZ-22); FUNCTIONS IN: protein binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: nuclear speck, nucleolus, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: RNA recognition motif and CCHC-type zinc finger domains containing protein (TAIR:AT2G24590.1); Has 12597 Blast hits to 10987 proteins in 687 species: Archae - 4; Bacteria - 845; Metazoa - 6508; Fungi - 1364; Plants - 2624; Viruses - 137; Other Eukaryotes - 1115 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    15306544..15309035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119307.4 → NP_194886.1  serine/arginine-rich 22 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194886.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23646, O81126
    UniProtKB/TrEMBL
    A0A178V2N6, A0A5S9XYC9, A0A654FV12
    Conserved Domains (2) summary
    pfam00098
    Location:100 → 114
    zf-CCHC; Zinc knuckle
    cd12373
    Location:3 → 71
    RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

  2. NM_001085005.1 → NP_001078474.1  serine/arginine-rich 22 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078474.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23646, O81126
    UniProtKB/TrEMBL
    A0A178V2N6, A0A5S9XYC9, A0A654FV12
    Conserved Domains (2) summary
    pfam00098
    Location:100 → 114
    zf-CCHC; Zinc knuckle
    cd12373
    Location:3 → 71
    RRM_SRSF3_like; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81126.1

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