VPS15 protein kinase family protein / WD-40 repeat family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: VPS15
Official Full Name: protein kinase family protein / WD-40 repeat family protein
Primary source: TAIR:AT4G29380
Locus tag: AT4G29380
See related: Araport:AT4G29380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana vacuolar protein sorting 15; AtVPS15; F17A13.200; F17A13_200; vacuolar protein sorting 15
Summary: The gene encodes phosphatidylinositol 3- kinase involved in the development and germination of pollen through the biosynthesis of phosphatidylinositol 3-phosphate (PI3P).
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Genomic context

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See VPS15 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 11

Sequence:: Chromosome: 4; NC_003075.7 (14458648..14465684)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrated that AtVPS15 might interact directly with AtVPS34 and suggested that AtVPS15 is very important for pollen germination, possibly through modulation of the activity of PI3-kinase.
Title: Arabidopsis AtVPS15 plays essential roles in pollen germination possibly by interacting with AtVPS34.
Data suggest that AtVPS15 (At4g29380; NP_194667.1) functions in pollen development and germination by regulating PI3P biosynthesis in Arabidopsis.
Title: Arabidopsis AtVPS15 is essential for pollen development and germination through modulating phosphatidylinositol 3-phosphate formation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001341967.1

Supported by ESTs:

NM_119083.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in late endosome to vacuole transport	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen germination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pollen germination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in Golgi apparatus	ISM Inferred from Sequence Model more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: protein kinase family protein / WD-40 repeat family protein

NP_194667.1

protein kinase family protein / WD-40 repeat family protein; FUNCTIONS IN: protein serine/threonine kinase activity, binding, protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, N-terminal protein myristoylation; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), WD40 repeat 2 (InterPro:IPR019782), Armadillo-like helical (InterPro:IPR011989), WD40 repeat (InterPro:IPR001680), HEAT, type 2 (InterPro:IPR021133), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), WD40 repeat-like-containing domain (InterPro:IPR011046), Protein kinase, catalytic domain (InterPro:IPR000719), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), Armadillo-type fold (InterPro:IPR016024), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT1G33770.1); Has 29441 Blast hits to 28057 proteins in 1177 species: Archae - 18; Bacteria - 2884; Metazoa - 11045; Fungi - 5111; Plants - 4360; Viruses - 46; Other Eukaryotes - 5977 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14458648..14465684

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119083.3 → NP_194667.1 protein kinase family protein / WD-40 repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194667.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M0E5

UniProtKB/TrEMBL

A0A178UW36

Conserved Domains (4) summary

cd13980
Location:16 → 303

STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15

sd00044
Location:652 → 682

HEAT; HEAT repeat [structural motif]

sd00039
Location:1085 → 1129

7WD40; WD40 repeat [structural motif]

cl25539
Location:1071 → 1325

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001341967.1 → NP_001329182.1 protein kinase family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UXY8, A0A1P8B6X9