ckl4 casein kinase I-like 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ckl4
Official Full Name: casein kinase I-like 4
Primary source: TAIR:AT4G28860
Locus tag: AT4G28860
See related: Araport:AT4G28860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: casein kinase I-like 4; F16A16.30; F16A16_30
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Genomic context

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See ckl4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 13

Sequence:: Chromosome: 4; NC_003075.7 (14246260..14249872)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies show that CK1.3 (At4g28880) and CK1.4 (At4g28860) directly phosphorylate CRY2 at Ser-587 and Thr-603 in vitro and negatively regulate CRY2 stability, which are stimulated by blue light.
Title: Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084996.2

Supported by ESTs:

NM_119030.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	HDA more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blue light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	HDA more info	PubMed
acts_upstream_of_or_within response to blue light	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase I-like 4

NP_001078465.1

casein kinase I-like 4 (ckl4); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: nucleus, cytoplasm; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: casein kinase I-like 3 (TAIR:AT4G28880.1); Has 66559 Blast hits to 66129 proteins in 2357 species: Archae - 56; Bacteria - 11194; Metazoa - 25356; Fungi - 7762; Plants - 10062; Viruses - 362; Other Eukaryotes - 11767 (source: NCBI BLink).

NP_194615.2

casein kinase I-like 4 (ckl4); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: nucleus, cytoplasm; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: casein kinase I-like 3 (TAIR:AT4G28880.1); Has 66689 Blast hits to 66255 proteins in 2362 species: Archae - 56; Bacteria - 11242; Metazoa - 25400; Fungi - 7755; Plants - 10110; Viruses - 362; Other Eukaryotes - 11764 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14246260..14249872

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119030.4 → NP_194615.2 casein kinase I-like 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194615.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q56YK2, Q67Y90, Q8LPI7, Q9SVV3

UniProtKB/TrEMBL

A0A178V3L4, A0A5S9XX82

Conserved Domains (1) summary

cl21453
Location:8 → 282

PKc_like; Protein Kinases, catalytic domain
NM_001084996.2 → NP_001078465.1 casein kinase I-like 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078465.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V3L4

Conserved Domains (2) summary

COG0515
Location:8 → 359

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cl21453
Location:8 → 282

PKc_like; Protein Kinases, catalytic domain