MRL7 polyadenylate-binding protein 2-binding protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MRL7
Official Full Name: polyadenylate-binding protein 2-binding protein
Primary source: TAIR:AT4G28590
Locus tag: AT4G28590
See related: Araport:AT4G28590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtECB1; early chloroplast biogenesis 1; ECB1; Mesophyll-cell RNAi Library line 7; SUPPRESSOR OF VARIEGATION 4; SVR4; T5F17.40; T5F17_40
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Genomic context

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See MRL7 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (14125212..14127082, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified REGULATOR OF CHLOROPLAST BIOGENESIS (RCB)/At4g28590 as a dual-targeted nuclear/plastidial phytochrome signaling component required for plastidial RNA polymerase assembly. RCB controls photosynthesis-associated plastid-encoded genes expression by interacting with phytochromes and promoting their localization to photobodies for the degradation of the transcriptional regulators PIF1 and PIF3.
Title: Phytochrome activates the plastid-encoded RNA polymerase for chloroplast biogenesis via nucleus-to-plastid signaling.
Data indicate that SUPPRESSOR OF VARIEGATION 4 (SVR4, At4g28590) and SVR4-like (At2g31840) are required for proper function of the plastid transcriptional machinery.
Title: SVR4 (suppressor of variegation 4) and SVR4-like: two proteins with a role in proper organization of the chloroplast genetic machinery.
AtECB1 may play a role in thioredoxin signaling to regulate plastid gene expression and chloroplast development. [ECB1]
Title: AtECB1/MRL7, a thioredoxin-like fold protein with disulfide reductase activity, regulates chloroplast gene expression and chloroplast biogenesis in Arabidopsis thaliana.
Chloroplast development was arrested upon loss of MRL7 function and the expression of plastid-encoded genes transcribed by plastid-encoded RNA polymerase was significantly reduced in MRL7 knock-down and knock-out plants.
Title: Two novel proteins, MRL7 and its paralog MRL7-L, have essential but functionally distinct roles in chloroplast development and are involved in plastid gene expression regulation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119001.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloroplast organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast nucleoid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polyadenylate-binding protein 2-binding protein

NP_194588.2

FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 10 growth stages; BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT2G31840.1); Has 114 Blast hits to 112 proteins in 39 species: Archae - 2; Bacteria - 0; Metazoa - 17; Fungi - 6; Plants - 67; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink).