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PPI1 proton pump interactor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828859, updated on 18-Sep-2024

Summary

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Official Symbol
PPI1
Official Full Name
proton pump interactor 1
Primary source
TAIR:AT4G27500
Locus tag
AT4G27500
See related
Araport:AT4G27500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F27G19.100; F27G19_100; proton pump interactor 1
Summary
interacts with H+-ATPase, and regulates its activity
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Genomic context

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See PPI1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
7
Sequence:
Chromosome: 4; NC_003075.7 (13743011..13746211)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene 3'-5'-exoribonuclease family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 2-isopropylmalate synthase Neighboring gene ncRNA Neighboring gene early nodulin-like protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intracellular localisation of PPI1 (proton pump interactor, isoform 1), a regulatory protein of the plasma membrane H(+)-ATPase of Arabidopsis thaliana. Bonza MC, et al. Plant Biol (Stuttg), 2009 Nov. PMID 19796364
  2. Characterization of the interaction between the plasma membrane H-ATPase of Arabidopsis thaliana and a novel interactor (PPI1). Viotti C, et al. FEBS J, 2005 Nov. PMID 16279950
  3. The proton pump interactor (Ppi) gene family of Arabidopsis thaliana: expression pattern of Ppi1 and characterisation of knockout mutants for Ppi1 and 2. Anzi C, et al. Plant Biol (Stuttg), 2008 Mar. PMID 18304198
  4. A novel interaction partner for the C-terminus of Arabidopsis thaliana plasma membrane H+-ATPase (AHA1 isoform): site and mechanism of action on H+-ATPase activity differ from those of 14-3-3 proteins. Morandini P, et al. Plant J, 2002 Aug. PMID 12182706
  5. Tyrosine phosphorylation inhibits the interaction of 14-3-3 proteins with the plant plasma membrane H+-ATPase. Giacometti S, et al. Plant Biol (Stuttg), 2004 Jul. PMID 15248125

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPI1 is localised at the endoplasmic reticulum, from which it is recruited to the plasma membrane for interaction with H(+)-ATPase.
    Title: Intracellular localisation of PPI1 (proton pump interactor, isoform 1), a regulatory protein of the plasma membrane H(+)-ATPase of Arabidopsis thaliana.
  2. Data show that Ppi1 expression is strong in root and shoot vascular systems, particularly in meristematic and sink tissues, as well as in pollen, stigmas and siliques, but not in developing embryos.
    Title: The proton pump interactor (Ppi) gene family of Arabidopsis thaliana: expression pattern of Ppi1 and characterisation of knockout mutants for Ppi1 and 2.
  3. PPI1 can bind the H(+)-ATPase independently of the C-terminus conformation, but is not able to suppress the C-terminus auto-inhibitory action.
    Title: Characterization of the interaction between the plasma membrane H-ATPase of Arabidopsis thaliana and a novel interactor (PPI1).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001341859.1
NM_118885.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of proton transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of proton transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
proton pump interactor 1
NP_194480.2
  • proton pump interactor 1 (PPI1); FUNCTIONS IN: protein binding; INVOLVED IN: regulation of proton transport; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT5G36690.1); Has 56187 Blast hits to 35171 proteins in 2461 species: Archae - 533; Bacteria - 11472; Metazoa - 20772; Fungi - 6196; Plants - 2564; Viruses - 257; Other Eukaryotes - 14393 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    13743011..13746211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118885.4 → NP_194480.2  proton pump interactor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194480.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFB6, O23144, Q9SZS5
    UniProtKB/TrEMBL
    A0A7G2F2Y3
    Conserved Domains (2) summary
    PHA03269
    Location:373 → 473
    PHA03269; envelope glycoprotein C; Provisional
    TIGR02169
    Location:93 → 345
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_001341859.1 → NP_001328990.1  proton pump interactor 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UT56, A0A1P8B6C5, A0A384KB37, A0A654FTC5
    Conserved Domains (2) summary
    COG1340
    Location:102 → 338
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    NF033909
    Location:389 → 485
    opacity_OapA; opacity-associated protein OapA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23144.2

Gene LinkOut

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