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Dihydrolipoamide succinyltransferase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828798, updated on 18-Sep-2024

Summary

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Official Full Name
Dihydrolipoamide succinyltransferase
Primary source
TAIR:AT4G26910
Locus tag
AT4G26910
See related
Araport:AT4G26910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F10M23.250; F10M23_250
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Genomic context

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Location:
chromosome: 4
Exon count:
14
Sequence:
Chromosome: 4; NC_003075.7 (13519811..13523405, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase kinase 16 Neighboring gene HIS HF Neighboring gene START (StAR-related lipid-transfer) lipid-binding domain-containing protein Neighboring gene myb domain protein 97 Neighboring gene Galactosyltransferase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana. Condori-Apfata JA, et al. Plant Cell Physiol, 2021 Oct 1. PMID 33693904, Free PMC Article
  2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
  4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
  5. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.
    Title: Downregulation of the E2 Subunit of 2-Oxoglutarate Dehydrogenase Modulates Plant Growth by Impacting Carbon-Nitrogen Metabolism in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_118825.3
NM_179121.3
NM_179122.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dihydrolipoyllysine-residue succinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dihydrolipoamide succinyltransferase
NP_567761.1
  • Dihydrolipoamide succinyltransferase; FUNCTIONS IN: zinc ion binding, acyltransferase activity; INVOLVED IN: tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dihydrolipoamide succinyltransferase (InterPro:IPR006255), 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide succinyltransferase (TAIR:AT5G55070.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_849452.1
  • Dihydrolipoamide succinyltransferase; FUNCTIONS IN: zinc ion binding, acyltransferase activity; INVOLVED IN: tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide succinyltransferase (InterPro:IPR006255), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide succinyltransferase (TAIR:AT5G55070.1); Has 25893 Blast hits to 21481 proteins in 2394 species: Archae - 160; Bacteria - 15396; Metazoa - 785; Fungi - 512; Plants - 432; Viruses - 4; Other Eukaryotes - 8604 (source: NCBI BLink).
NP_849453.1
  • Dihydrolipoamide succinyltransferase; FUNCTIONS IN: zinc ion binding, acyltransferase activity; INVOLVED IN: tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), Dihydrolipoamide succinyltransferase (InterPro:IPR006255), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: Dihydrolipoamide succinyltransferase (TAIR:AT5G55070.1); Has 24826 Blast hits to 20752 proteins in 2368 species: Archae - 154; Bacteria - 14691; Metazoa - 760; Fungi - 487; Plants - 406; Viruses - 4; Other Eukaryotes - 8324 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    13519811..13523405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179121.3 → NP_849452.1  Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849452.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V2M2, A0A5S9XW61
    Conserved Domains (3) summary
    cd06849
    Location:92 → 165
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    PLN02226
    Location:1 → 463
    PLN02226; 2-oxoglutarate dehydrogenase E2 component
    pfam00198
    Location:250 → 461
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

  2. NM_118825.3 → NP_567761.1  Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567761.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E9W2, Q8H107, Q8LGI7, Q9SZ31
    UniProtKB/TrEMBL
    A0A178V3X4
    Conserved Domains (3) summary
    cd06849
    Location:93 → 166
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    PLN02226
    Location:1 → 464
    PLN02226; 2-oxoglutarate dehydrogenase E2 component
    pfam00198
    Location:251 → 462
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

  3. NM_179122.1 → NP_849453.1  Dihydrolipoamide succinyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849453.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8H107
    Conserved Domains (3) summary
    cd06849
    Location:1 → 67
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    PRK05704
    Location:2 → 365
    PRK05704; dihydrolipoamide succinyltransferase; Validated
    pfam00198
    Location:152 → 363
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H107.2

Gene LinkOut

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