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DTX35 detoxifying efflux carrier 35 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828669, updated on 18-Sep-2024

Summary

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Official Symbol
DTX35
Official Full Name
detoxifying efflux carrier 35
Primary source
TAIR:AT4G25640
Locus tag
AT4G25640
See related
Araport:AT4G25640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATDTX35; detoxifying efflux carrier 35; FFT; FLOWER FLAVONOID TRANSPORTER; L73G19.20; L73G19_20
Summary
Encodes a multidrug and toxin efflux family transporter. Involved in flavonoid metabolism, affecting Root growth, seed development and germination, and pollen development, release and viability.
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Genomic context

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See DTX35 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Sequence:
Chromosome: 4; NC_003075.7 (13076444..13079256, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene C2H2-like zinc finger protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene fibrillarin 2 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene ACD1-like protein Neighboring gene PPPDE putative thiol peptidase family protein Neighboring gene stress response NST1-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis pab1, a mutant with reduced anthocyanins in immature seeds from banyuls, harbors a mutation in the MATE transporter FFT. Kitamura S, et al. Plant Mol Biol, 2016 Jan. PMID 26608698
  2. An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development. Thompson EP, et al. J Exp Bot, 2010. PMID 19995827, Free PMC Article
  3. Two tonoplast MATE proteins function as turgor-regulating chloride channels in Arabidopsis. Zhang H, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28202726, Free PMC Article
  4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tonoplast proteins DTX33 and DTX35 function as turgor-regulating chloride channels in Arabidopsis.
    Title: Two tonoplast MATE proteins function as turgor-regulating chloride channels in Arabidopsis.
  2. FFT acts at the vacuolar membrane in anthocyanin accumulation in the Arabidopsis seed coat.
    Title: Arabidopsis pab1, a mutant with reduced anthocyanins in immature seeds from banyuls, harbors a mutation in the MATE transporter FFT.
  3. AtDTX35, a multidrug and toxin efflux family transporter, is required for anther dehiscence and pollen development. [AtDTX35]
    Title: An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development.
Submit: New GeneRIF Correction

General gene information

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NM_001341758.1
NM_118696.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anther dehiscence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flavonoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flavonoid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
detoxifying efflux carrier 35
NP_001190838.1
  • detoxifying efflux carrier 35 (DTX35); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity; INVOLVED IN: anther dehiscence, flavonoid metabolic process, pollen development; LOCATED IN: membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT4G00350.1).
NP_194294.2
  • detoxifying efflux carrier 35 (DTX35); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity; INVOLVED IN: anther dehiscence, flavonoid metabolic process, pollen development; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT4G00350.1); Has 11724 Blast hits to 11622 proteins in 2105 species: Archae - 230; Bacteria - 8860; Metazoa - 143; Fungi - 322; Plants - 1354; Viruses - 0; Other Eukaryotes - 815 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    13076444..13079256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001203909.1 → NP_001190838.1  detoxifying efflux carrier 35 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V331, A0A5S9XVS3, F4JTB2
    Conserved Domains (2) summary
    cd13132
    Location:34 → 468
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    TIGR00797
    Location:44 → 382
    matE; putative efflux protein, MATE family

  2. NM_118696.5 → NP_194294.2  detoxifying efflux carrier 35 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194294.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JTB3, Q0WWD0, Q9SZZ2
    UniProtKB/TrEMBL
    A0A178V331, A0A5S9XVS3
    Conserved Domains (2) summary
    cd13132
    Location:34 → 468
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    TIGR00797
    Location:44 → 382
    matE; putative efflux protein, MATE family

  3. NM_001341758.1 → NP_001329321.1  detoxifying efflux carrier 35 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V331, A0A1P8B7C3, A0A5S9XVS3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4JTB3.1

Gene LinkOut

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