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FIB2 fibrillarin 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828668, updated on 18-Sep-2024

Summary

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Official Symbol
FIB2
Official Full Name
fibrillarin 2
Primary source
TAIR:AT4G25630
Locus tag
AT4G25630
See related
Araport:AT4G25630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATFIB2; fibrillarin 2; L73G19.10; L73G19_10
Summary
encodes a fibrillarin, a key nucleolar protein in eukaryotes which associates with box C/D small nucleolar RNAs (snoRNAs) directing 2'-O-ribose methylation of the rRNA. This gene also encodes a novel box C/D snoRNA, U60.2f in its fifth intron that accumulates in seedlings and that their targeted residue on the 25 S rRNA is methylated.
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Genomic context

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See FIB2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
7
Sequence:
Chromosome: 4; NC_003075.7 (13074090..13076432)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Oxoglutarate/iron-dependent oxygenase Neighboring gene C2H2-like zinc finger protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene detoxifying efflux carrier 35 Neighboring gene ACD1-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plant viral proteins and fibrillarin: the link to complete the infective cycle. Decle-Carrasco S, et al. Mol Biol Rep, 2021 May. PMID 34036480
  2. Novel Ribonuclease Activity Differs between Fibrillarins from Arabidopsis thaliana. Rodriguez-Corona U, et al. Front Plant Sci, 2017. PMID 29163603, Free PMC Article
  3. Two RNA-binding sites in plant fibrillarin provide interactions with various RNA substrates. Rakitina DV, et al. Nucleic Acids Res, 2011 Nov 1. PMID 21785141, Free PMC Article
  4. Arabidopsis ribosomal proteins RPL23aA and RPL23aB are differentially targeted to the nucleolus and are disparately required for normal development. Degenhardt RF, et al. Plant Physiol, 2008 May. PMID 18322146, Free PMC Article
  5. Fibrillarin genes encode both a conserved nucleolar protein and a novel small nucleolar RNA involved in ribosomal RNA methylation in Arabidopsis thaliana. Barneche F, et al. J Biol Chem, 2000 Sep 1. PMID 10829025

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plant viral proteins and fibrillarin: the link to complete the infective cycle.
    Title: Plant viral proteins and fibrillarin: the link to complete the infective cycle.
  2. ELENA1 can dissociate the FIB2/MED19a complex and release FIB2 from PR1 promoter to enhance PR1 expression.
    Title: ELF18-INDUCED LONG NONCODING RNA 1 evicts fibrillarin from mediator subunit to enhance PATHOGENESIS-RELATED GENE 1 (PR1) expression.
  3. The data indicates that AtFib2 possesses two RNA-binding sites in the central (138-179 amino acids) and C-terminal (225-281 amino acids) parts of the protein, respectively.
    Title: Two RNA-binding sites in plant fibrillarin provide interactions with various RNA substrates.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_118695.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA nuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA methylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within rRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
fibrillarin 2
NP_567724.1
  • fibrillarin 2 (FIB2); FUNCTIONS IN: snoRNA binding; INVOLVED IN: response to salt stress, RNA methylation, rRNA processing; LOCATED IN: nucleolus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fibrillarin (InterPro:IPR000692); BEST Arabidopsis thaliana protein match is: fibrillarin 1 (TAIR:AT5G52470.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    13074090..13076432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118695.4 → NP_567724.1  fibrillarin 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94AH9, Q9SZZ1
    UniProtKB/TrEMBL
    A0A178UZ20, A0A5S9XW69
    Conserved Domains (1) summary
    PTZ00146
    Location:75 → 315
    PTZ00146; fibrillarin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94AH9.2

Gene LinkOut

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