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SIC hydroxyproline-rich glycoprotein family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828552, updated on 18-Sep-2024

Summary

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Official Symbol
SIC
Official Full Name
hydroxyproline-rich glycoprotein family protein
Primary source
TAIR:AT4G24500
Locus tag
AT4G24500
See related
Araport:AT4G24500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F22K18.300; F22K18_300; SICKLE
Summary
Encodes a proline-rich protein SICKLE (SIC). Required for development and abiotic stress tolerance. Involved in microRNA biogenesis.
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Genomic context

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See SIC in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_003075.7 (12658433..12660667)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene GATA-type zinc finger protein with TIFY domain-containing protein Neighboring gene Protein kinase superfamily protein Neighboring gene RAB geranylgeranyl transferase alpha subunit 1 Neighboring gene ncRNA Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene P450 reductase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs. Wu C, et al. Plant Physiol, 2023 Jul 3. PMID 36974901, Free PMC Article
  2. The Arabidopsis sickle Mutant Exhibits Altered Circadian Clock Responses to Cool Temperatures and Temperature-Dependent Alternative Splicing. Marshall CM, et al. Plant Cell, 2016 Oct. PMID 27624757, Free PMC Article
  3. Arabidopsis proline-rich protein important for development and abiotic stress tolerance is involved in microRNA biogenesis. Zhan X, et al. Proc Natl Acad Sci U S A, 2012 Oct 30. PMID 23071326, Free PMC Article
  4. ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling. Karampelias M, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26888284, Free PMC Article
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.
    Title: Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.
  2. Data show that ROTUNDA3 (RON3; At4g24500) protein as a regulator of the protein phosphatase 2A-driven PIN-FORMED (PIN) auxin transport recycling and its importance in auxin transport-related plant developmental programs.
    Title: ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001203893.1
NM_001341679.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within entrainment of circadian clock IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization involved in auxin polar transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of auxin polar transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hydroxyproline-rich glycoprotein family protein
NP_001190822.1
  • hydroxyproline-rich glycoprotein family protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages.
NP_001320056.1
  • hydroxyproline-rich glycoprotein family protein; Has 273 Blast hits to 270 proteins in 79 species: Archae - 0; Bacteria - 25; Metazoa - 136; Fungi - 37; Plants - 63; Viruses - 0; Other Eukaryotes - 12 (source: NCBI BLink).
NP_567704.1
  • hydroxyproline-rich glycoprotein family protein; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12658433..12660667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118583.4 → NP_567704.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567704.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8H0Z3, Q94AJ0, Q9SB47
    UniProtKB/TrEMBL
    A0A178V4U1, A0A5S9XVW1
    Conserved Domains (1) summary
    pfam15502
    Location:127 → 273
    MPLKIP; M-phase-specific PLK1-interacting protein

  2. NM_001203893.1 → NP_001190822.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8H0Z3, Q94AJ0, Q9SB47
    UniProtKB/TrEMBL
    A0A178V4U1, A0A5S9XVW1
    Conserved Domains (1) summary
    pfam15502
    Location:127 → 273
    MPLKIP; M-phase-specific PLK1-interacting protein

  3. NM_001341679.1 → NP_001320056.1  hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V4U1, A0A5S9XVW1, A0A7G2F3E8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SB47.1

Gene LinkOut

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