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CLT2 CRT (chloroquine-resistance transporter)-like transporter 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828548, updated on 18-Sep-2024

Summary

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Official Symbol
CLT2
Official Full Name
CRT (chloroquine-resistance transporter)-like transporter 2
Primary source
TAIR:AT4G24460
Locus tag
AT4G24460
See related
Araport:AT4G24460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CRT (chloroquine-resistance transporter)-like transporter 2; T22A6.290; T22A6_290
Summary
Encodes one of the CRT-Like transporters (CLT1/AT5G19380, CLT2/AT4G24460, CLT3/AT5G12170). Required for glutathione homeostasis and stress responses. Mutants lacking these transporters are heavy metal-sensitive, glutathione(GSH)-deficient, and hypersensitive to Phytophthora infection.
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Genomic context

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See CLT2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Sequence:
Chromosome: 4; NC_003075.7 (12642844..12645501)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA gamma chain / TFIIA-gamma (TFIIA-S) Neighboring gene phosphoglucan, water dikinase Neighboring gene GATA-type zinc finger protein with TIFY domain-containing protein Neighboring gene Protein kinase superfamily protein Neighboring gene RAB geranylgeranyl transferase alpha subunit 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. Maughan SC, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080670, Free PMC Article
  2. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
  3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001203891.1
NM_001341676.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to oomycetes IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glutathione transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in plastid IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CRT (chloroquine-resistance transporter)-like transporter 2
NP_001190820.1
  • CRT (chloroquine-resistance transporter)-like transporter 2 (CLT2); CONTAINS InterPro DOMAIN/s: Chloroquine resistance transporter related (InterPro:IPR013936); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 3 (TAIR:AT5G12170.2).
NP_194177.2
  • CRT (chloroquine-resistance transporter)-like transporter 2 (CLT2); INVOLVED IN: response to cadmium ion, defense response to oomycetes, glutathione transport; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chloroquine resistance transporter related (InterPro:IPR013936); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 3 (TAIR:AT5G12170.2); Has 203 Blast hits to 201 proteins in 65 species: Archae - 2; Bacteria - 34; Metazoa - 4; Fungi - 0; Plants - 75; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12642844..12645501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001341675.1 → NP_001329790.1  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B8S9

  2. NM_118579.4 → NP_194177.2  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194177.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1L4X0, Q84TI1, Q9STU9
    UniProtKB/TrEMBL
    A0A5S9XWC1
    Conserved Domains (1) summary
    cl23754
    Location:94 → 417
    EamA; EamA-like transporter family

  3. NM_001203891.1 → NP_001190820.1  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1L4X0, Q84TI1, Q9STU9
    UniProtKB/TrEMBL
    A0A5S9XWC1
    Conserved Domains (1) summary
    cl23754
    Location:94 → 417
    EamA; EamA-like transporter family

  4. NM_001341676.1 → NP_001329789.1  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B8T5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L4X0.1

Gene LinkOut

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