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FtsHi1 FtsH extracellular protease family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828494, updated on 18-Sep-2024

Summary

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Official Symbol
FtsHi1
Official Full Name
FtsH extracellular protease family
Primary source
TAIR:AT4G23940
Locus tag
AT4G23940
See related
Araport:AT4G23940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACCUMULATION AND REPLICATION OF CHLOROPLASTS 1; ARC1; FTSH inactive protease 1; T32A16.110; T32A16_110
Summary
Encodes FtsHi1. Localizes to the chloroplast envelope membrane. Functions in chloroplast biogenesis and division.
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Genomic context

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See FtsHi1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
14
Sequence:
Chromosome: 4; NC_003075.7 (12437108..12442030)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene UDP-D-glucose/UDP-D-galactose 4-epimerase 2 Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Galactose-binding protein Neighboring gene F-box family protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The translocon protein FtsHi1 is an ATP-dependent DNA/RNA helicase that prevents R-loop accumulation in chloroplasts. Chai X, et al. New Phytol, 2024 Mar. PMID 38084045
  2. FtsHi1/ARC1 is an essential gene in Arabidopsis that links chloroplast biogenesis and division. Kadirjan-Kalbach DK, et al. Plant J, 2012 Dec. PMID 22900897
  3. Chloroplast Division and Expansion Is Radically Altered by Nuclear Mutations in Arabidopsis thaliana. Pyke KA, et al. Plant Physiol, 1992 Jul. PMID 16668963, Free PMC Article
  4. The distinctive roles of five different ARC genes in the chloroplast division process in Arabidopsis. Marrison JL, et al. Plant J, 1999 Jun. PMID 10417716
  5. A Ycf2-FtsHi Heteromeric AAA-ATPase Complex Is Required for Chloroplast Protein Import. Kikuchi S, et al. Plant Cell, 2018 Nov. PMID 30309901, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The translocon protein FtsHi1 is an ATP-dependent DNA/RNA helicase that prevents R-loop accumulation in chloroplasts.
    Title: The translocon protein FtsHi1 is an ATP-dependent DNA/RNA helicase that prevents R-loop accumulation in chloroplasts.
  2. ARC1 was isolated and discovered it encodes FtsHi1 (At4g23940); analysis revealed FtsHi1 (At4g23940) functions in an essential, envelope-associated process that may couple plastid development with division
    Title: FtsHi1/ARC1 is an essential gene in Arabidopsis that links chloroplast biogenesis and division.
Submit: New GeneRIF Correction

General gene information

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NM_118526.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables chloroplast protein-transporting ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chloroplast fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chloroplast organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chloroplast organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plastid fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein import into chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ycf2/FtsHi complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
FtsH extracellular protease family
NP_567691.1
  • FtsH extracellular protease family; FUNCTIONS IN: in 6 functions; INVOLVED IN: proteolysis; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA+ type, core (InterPro:IPR003593), Peptidase M41 (InterPro:IPR000642); BEST Arabidopsis thaliana protein match is: FtsH extracellular protease family (TAIR:AT2G30950.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12437108..12442030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118526.3 → NP_567691.1  FtsH extracellular protease family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22993
    UniProtKB/TrEMBL
    A0A178V628, A0A5S9XVN8, A0A654FSC0
    Conserved Domains (3) summary
    TIGR01241
    Location:373 → 899
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:466 → 606
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:701 → 895
    Peptidase_M41; Peptidase family M41
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22993.1

Gene LinkOut

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