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MBD1 methyl-CPG-binding domain 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828371, updated on 18-Sep-2024

Summary

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Official Symbol
MBD1
Official Full Name
methyl-CPG-binding domain 1
Primary source
TAIR:AT4G22745
Locus tag
AT4G22745
See related
Araport:AT4G22745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
methyl-CPG-binding domain 1
Summary
Protein containing methyl-CpG-binding domain.
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Genomic context

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See MBD1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_003075.7 (11947210..11948804, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene glycine-rich protein Neighboring gene DHHC-type zinc finger protein Neighboring gene methylsterol monooxygenase 1-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylated DNA-binding proteins from Arabidopsis. Ito M, et al. Plant Physiol, 2003 Dec. PMID 14605234, Free PMC Article
  2. Characterization of Arabidopsis thaliana methyl-CpG-binding domain (MBD) proteins. Zemach A, et al. Plant J, 2003 Jun. PMID 12787239
  3. Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. Feng C, et al. J Genet Genomics, 2021 May 20. PMID 34144927
  4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
  5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_118401.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables cytosine C-5 DNA demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyl-CpG binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methyl-CPG-binding domain 1
NP_567667.2
  • methyl-CPG-binding domain 1 (MBD1); FUNCTIONS IN: methyl-CpG binding, DNA binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739), Zinc finger, CW-type (InterPro:IPR011124); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 4 (TAIR:AT3G63030.1); Has 113 Blast hits to 113 proteins in 19 species: Archae - 0; Bacteria - 0; Metazoa - 4; Fungi - 0; Plants - 109; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    11947210..11948804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118401.6 → NP_567667.2  methyl-CPG-binding domain 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567667.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49655, Q5XEN5
    UniProtKB/TrEMBL
    A0A178UWM3, A0A654FRX8
    Conserved Domains (2) summary
    cd01396
    Location:114 → 189
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam07496
    Location:55 → 98
    zf-CW; CW-type Zinc Finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XEN5.1

Gene LinkOut

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